| 100% | OCTOPI | 6 | Ocean creatures with nearly triple the neural wiring of humans |
| 33% | CENTAUR | 7 | Horse creature with the torso of a man |
| 32% | PLATYPUS | 8 | Creature with a duck bill and the body of a mammal |
| 31% | MERMAID | 7 | Half human, half-fish creature of the water |
| 31% | SMALLMINDED | 11 | Petty creature of the Rockies, with 56-Across? |
| 30% | OTTER | 5 | Creature with "Underwater eyes, an eel's / Oil of water body," per the poet Ted Hughes |
| 30% | HARPY | 5 | Mythical creature with the face of a woman and the body of a bird |
| 30% | STINGRAY | 8 | Marine creature with one or more venomous spines at the base of the tail |
| 30% | ENYA | 4 | Singer with the triple-platinum album "The Memory of Trees" |
| 29% | SCHNAUZER | 9 | Wire-haired breed of dog of the terrier type with a greyish coat |
| 29% | RUR | 3 | 1921 play that ends with the extinction of the human race |
| 29% | GIRAFFE | 7 | Creature with distinctive features seen at the ends of 17- and 53-Across and 11- and 24-Down |
| 29% | OCTOPI | 6 | Ocean creatures with three hearts |
| 29% | HUMAN | 5 | With 2-Down, it has roughly tripled in size since the time of australopithecines |
| 29% | DEADSEA | 7 | Body of water that's nearly 10 times saltier than the ocean |
| 29% | SNARE | 5 | Side drum with a rattle of metal wires on the bottom head |
| 29% | SPHINX | 6 | Egyptian attraction with a human head on the body of a lion |
| 29% | TIGERSHARK | 10 | Large creature of warm seas with dark vertical stripes on the body |
| 29% | COCKATRICE | 10 | Mythical creature; a two-legged dragon with the head of a cockerel |
| 29% | CATFISH | 7 | Ocean creature with whiskers; Schulman documentary |
| 28% | JERI | 4 | “The Courage of Strangers: Coming of Age with the Human Rights Movement” memoirist Laber |
| 28% | NEUTRON | 7 | Uncharged elementary particle with a mass nearly equal to that of the proton |
| 28% | KNEE | 4 | Joint of the human leg connecting the tibia and fibula with the femur |
| 28% | ONION | 5 | Source of the headline "Study Finds Blame Now Fastest Human Reflex," with "The" |
| 28% | SEAHORSE | 8 | The males of this ocean creature carry the babies |
| 28% | SEASNAKE | 8 | Venomous marine creature of the Indian and Pacific Oceans such as the yellow-bellied — |
| 28% | VAMPIRE | 7 | Creature who might disagree with the saying at the ends of 17-, 22-, 48- and 56-Across |
| 28% | HARPY | 5 | Creature in Greek mythology with the head and trunk of a woman and wings of a bird |
| 28% | RED | 3 | With 3-Down and 4-Across, the human body makes around 200 billion of them per day |
| 27% | FRIENDS | 7 | Nearly all of its episode titles start "The One With ..." |