| 100% | LORENA | 6 | Ochoa who was the first #1-ranked golfer from Mexico |
| 100% | LORENA | 6 | Ochoa who was the first No. 1 ranked golfer from Mexico |
| 55% | LORENA | 6 | Ochoa who was the top-ranked female golfer when she retired |
| 53% | ELLEN | 5 | Astronaut Ochoa who was the first Latina in space |
| 51% | ANAND | 5 | Viswanathan who was the first chess grandmaster from India |
| 51% | SANTOS | 6 | George who was the first Republican expelled from Congress |
| 50% | LYDIA | 5 | Golfer Ko who was the youngest professional to be ranked #1 |
| 48% | CLINTON | 7 | Hillary ___, politician and icon who was the first female senator from New York |
| 48% | ANNE | 4 | Bradstreet who was the first published writer from England's North American colonies (1650) |
| 46% | LORENAOCHOA | 11 | She was the first Mexican golfer to rank #1 in the world and received golf's Bob Jones Award in 2011: 2 wds. |
| 45% | LUKEAIKINS | 10 | American skydiver who was the first to land safely without a parachute or wingsuit from mid-tropospheric altitude: 2 wds. |
| 44% | ANA | 3 | Tennis player Ivanovic who was ranked No. 1 in the world in 2008 |
| 44% | LORENAOCHOA | 11 | Mexican golfer who was #1 in the LPGA from April 2007 to May 2010: 2 wds. |
| 44% | YANITSENG | 9 | Taiwanese golfer who was #1 in the LPGA from February 2011 to March 2013: 2 wds. |
| 43% | SANIA | 5 | ___ Mirza, retired Indian tennis star who was ranked No. 1 in the world in doubles |
| 43% | OCHOA | 5 | Lorena who was the #1 female golfer for 158 consecutive weeks |
| 42% | INBEEPARK | 9 | South Korean golfer who was #1 in the LPGA from June to October 2015: 2 wds. |
| 42% | DOLLY | 5 | Sheep who was the first cloned mammal |
| 42% | NYAD | 4 | Diana who was the first person to swim from Cuba to Florida without the aid of shark protection (2013) |
| 42% | LAIKA | 5 | Dog who was the first animal in space |
| 42% | ELMO | 4 | Lincoln who was the first screen adult Tarzan |
| 42% | DEE | 3 | Sandra who was the first to play "Gidget" |
| 42% | RENO | 4 | Janet who was the first female attorney general |
| 42% | SEAN | 4 | Actor Connery who was the first James Bond |
| 42% | OMAR | 4 | Bradley who was the first Joint Chiefs chairman |
| 42% | SEAN | 4 | Parker who was the first president of Facebook |
| 42% | SHEPARD | 7 | Alan who was the first American in space |
| 42% | ROLLO | 5 | Viking who was the first ruler of Normandy |
| 42% | EVA | 3 | Perón who was the First Lady of Argentina |
| 42% | LAURABUSH | 9 | Former Girl Scout who was First Lady of the United States from 2001 to 2009 (2 wds.) |