| 100% | ADDICTIVE | 9 | Of a harmful substance that creates dependence |
| 50% | UREA | 4 | Substance that showed, in 1828, that something previously produced only as a by-product of life, could be created in the lab |
| 48% | LAVA | 4 | Substance that flows out of a volcano |
| 47% | LYE | 3 | Substance that's a homophone of a falsehood |
| 46% | BEE | 3 | Insect that creates a lot of buzz? |
| 45% | SCANNER | 7 | Device that creates a digital copy of an image |
| 44% | ODORS | 5 | The properties of a substance that activate the sense of smell |
| 43% | ORE | 3 | Metallic substance that's a resource in the game The Settlers of Catan |
| 42% | PRINTER | 7 | A device that creates hard copies of digital files |
| 40% | DUST | 4 | Fairy ___, magical substance that you can sprinkle for a touch of enchantment with your "Fairy" Halloween costume |
| 40% | AFI | 3 | Movie org. that created a top-100 list from which all of this puzzle's quotes come |
| 40% | KID | 3 | "Diary of a Wimpy ___," book series and media franchise created by Jeff Kinney that follows a middle-schooler |
| 39% | URIC | 4 | Type of acid that is created when the body breaks down substances called purines |
| 39% | CRASHING | 8 | TV series created by comedian Pete Holmes that features a fictional version of himself |
| 39% | OOBLECK | 7 | Gooey substance made of cornstarch and water, with a name that comes from Dr. Seuss |
| 38% | SAMSON | 6 | __ & Delilah, Biblical tale of a harmful haircut |
| 38% | MAM | 3 | The org. that created outrage in 2015 by acquiring "Eggs Benedict", a portrait of the Pope made with colorful condoms (abbr.) |
| 37% | CATALYST | 8 | Substance that accelerates a chemical reaction |
| 37% | CATALYST | 8 | Substance that boosts a chemical reaction |
| 37% | CATALYST | 8 | Substance that precipitates a chemical reaction |
| 37% | CATALYST | 8 | Substance that speeds up a reaction |
| 37% | INITIATOR | 9 | Substance that starts a chain reaction |
| 37% | SPIT | 4 | Substance that flattens a kiss curl |
| 37% | TITER | 5 | Concentration of a substance |
| 37% | ASSAY | 5 | Appraisal of a substance |
| 37% | CRUDEOIL | 8 | Substance that is refined to create petroleum |
| 37% | SAND | 4 | Beach particles that Sam Raimi studied under a microscope to create the anti-hero of "Spider-Man 3" |
| 37% | PROBIOTIC | 9 | Substance that promotes growth of good bacteria |
| 37% | BOTOX | 5 | Substance that gets rid of frown lines |
| 37% | INHIBITOR | 9 | Substance that slows down a chemical reaction |