| 100% | SKELETONKEY | 11 | One can open many locks |
| 51% | KEYS | 4 | They can open locks |
| 47% | TAB | 3 | You can open one in a Web browser |
| 47% | KEY | 3 | What can open a locked diary |
| 47% | ANGLER | 6 | One opening a can of worms? |
| 47% | ACCT | 4 | You can open one at a bank, for short |
| 47% | TAB | 3 | You can open a new one in a browser |
| 46% | ANGLER | 6 | One who opens a can of worms? |
| 46% | POPTOPWARNER | 12 | One cautioning about opening a soda can? |
| 46% | ANGLER | 6 | One opening up a can of worms? |
| 46% | EMAIL | 5 | Many a meeting could have been one |
| 46% | ATON | 4 | More than one can count |
| 44% | TAB | 3 | One web page of many opened in one browser window |
| 44% | ACE | 3 | One of many served at this year's Australian Open |
| 44% | TAB | 3 | One web page of many opened on a browser window |
| 44% | GAMEPOINT | 9 | When one more score can end the match |
| 43% | TAB | 3 | One of many opened while exploring a Wikipedia rabbit hole, maybe |
| 43% | AMBIGUOUS | 9 | Unclear, can be interpreted in more than one way |
| 42% | ESC | 3 | Key that can close a window, but not open one |
| 42% | SCENARIO | 8 | One variation of many of how a situation could go |
| 41% | ODED | 4 | Had more than one could handle |
| 41% | DAIRY | 5 | Aisle in the grocery store where one can find ice cream, milk, yogurt, and more |
| 41% | CANDY | 5 | Aisle in the grocery store where one can find chocolates, chewing gum, marshmallows, and more |
| 41% | BREAKFAST | 9 | Aisle in the grocery store where one can find cereals, waffles, pancake mixes, and more |
| 41% | TAB | 3 | You might have more than one open in a Web browser |
| 40% | CANNED | 6 | ___ goods, aisle in the grocery store where one can find packaged chicken, beef, veggies, and more |
| 40% | SLEEP | 5 | Post a nice sauna session, one could benefit from a deeper and more relaxed slumber or ___ |
| 40% | PRIES | 5 | Tries to get clams to open up, in more ways than one |
| 40% | CARE | 4 | Personal ___, aisle in the grocery store where one can find shampoo, hair color, moisturizers, perfumes, and more |
| 40% | BEVERAGE | 8 | Aisle in the grocery store where one can find fruit drinks, soft drinks, coffee, tea, and more |