| 100% | CHROMOSOME | 10 | One of 46 for you and me, but one of 64 for guinea pigs |
| 40% | DOG | 3 | Marley of "Marley and Me," for one |
| 38% | OURS | 4 | For you and me |
| 38% | HUMAN | 5 | For you and me |
| 36% | USAGE | 5 | You and me have period of employment |
| 36% | WEASEL | 6 | You and I organise sale of animal |
| 36% | WEASEL | 6 | You and I organise sale of creature |
| 36% | OUR | 3 | Pronoun for you and me |
| 36% | DEBORAHKERR | 11 | "The King and I" actress who was nominated for six Oscars but never won one: 2 wds. |
| 36% | OURS | 4 | It's for you and me |
| 35% | BONO | 4 | I am a member of U2 and was named one of the Time Persons of the Year in 2005 for my philanthropic efforts |
| 35% | FELONY | 6 | For a class E one of these you could get up to 5 years and a $250,000 fine |
| 34% | USA | 3 | The land that was made for you and me |
| 34% | WOE | 3 | You and I have nothing but sadness |
| 34% | WOE | 3 | You and I have nothing but misery |
| 34% | WOE | 3 | You and I have nothing but grief |
| 34% | WOE | 3 | You and I have nothing but gloom |
| 34% | OATH | 4 | “I swear to tell the truth, the whole truth, and nothing but the truth, so help me God,” for one |
| 34% | JLO | 3 | She said, "I'm like a little roach. You think I'm gone for good ... But then you go to get a glass of water in the middle of the night, and boom! I got an album." |
| 34% | AMERICA | 7 | Land made for you and me, in a Woody Guthrie song |
| 34% | SLICE | 5 | "Take a ___ of lime or lemon and add it to your drink. You can also keep one aside for garnishing!" |
| 33% | SPRING | 6 | I'm the time of year for cleaning and picnics |
| 33% | LABRAT | 6 | Guinea pig, for one: 2 wds. |
| 33% | EACH | 4 | "___ and every one of you..." |
| 33% | CAMPUS | 6 | Place of learning is effeminate to you and me |
| 32% | TAKE | 4 | "Can you ___ care of this for me?" |
| 32% | PATSY | 5 | With 6-Across, singer of the lyrics “I’m crazy for trying and crazy for crying / And I’m crazy for loving you” |
| 32% | CHEMICALSYMBOLS | 15 | He and I, but not she and you |
| 32% | HAY | 3 | Food for horses and guinea pigs |
| 32% | OATH | 4 | "I promise to tell the truth, the whole truth and nothing but the truth," for one |