| 100% | BAEZ | 4 | One of the first to record Dylan's songs |
| 56% | YEA | 3 | One of the first to raise a hand, usually |
| 56% | JONASSALK | 9 | One of the first to develop a polio vaccination |
| 54% | CHATROOM | 8 | One of the first ways to communicate online |
| 54% | ARP | 3 | One of the first artists to incorporate random chance |
| 53% | TWENTIETHCENTURY | 16 | One of the first Buicks to roll off the line? |
| 53% | THISISLANDEARTH | 15 | 1955 sci-fi film that was one of the first to use Technicolor |
| 52% | WASHINGTON | 10 | One of the first two states to permit marijuana for recreational use |
| 52% | COLORADO | 8 | One of the first two states to permit marijuana for recreational use |
| 52% | AOXOMOXOA | 9 | Palindromic 1969 rock album that was one of the first to use 16-track technology |
| 52% | OMAR | 4 | Ilhan ___, one of the first two Muslim women elected to Congress |
| 51% | ICET | 4 | One of the first musicians to have an "explicit content" sticker on an album |
| 51% | NAT | 3 | ___ "Sweetwater" Clifton, one of the first Black players to play in the NBA |
| 50% | MALIK | 5 | Surname of the first member to leave One Direction |
| 50% | ELLA | 4 | The First Lady of Song, to fans |
| 50% | OMAR | 4 | Minnesotan Ilhan who is one of the first two Muslim women elected to Congress |
| 50% | TENZINGNORGAY | 13 | Sherpa who was one of the first two people to conquer Mount Everest: 2 wds. |
| 49% | SARA | 4 | Bob Dylan's first wife and the title of a song about her |
| 49% | SUEDE | 5 | "Blue ___ Shoes" (1956 song that was one of the first rock and roll records) |
| 49% | GODS | 4 | "Men Like ___," 1923 novel by H.G. Wells that was one of the first to feature the idea of parallel universes |
| 48% | EDMUNDHILLARY | 13 | New Zealand mountaineer who was one of the first two people to conquer Mount Everest: 2 wds. |
| 48% | INDIEGOGO | 9 | Online platform that was one of the first websites to offer crowdfunding for business and personal goals |
| 48% | BABYLON | 7 | "___ 5," one of the first television series to use CGI as the primary method for its visual effects |
| 47% | CLINE | 5 | Patsy ___, "Walkin' After Midnight" singer who was one of the first country stars to cross over to pop music charts |
| 47% | EMI | 3 | One of the record industry's former Big Four |
| 47% | OLDS | 4 | One of the first automakers |
| 47% | APOSTLE | 7 | One of the first disciples |
| 47% | CREE | 4 | One of the First Nations |
| 47% | ADAM | 4 | One of the first mates |
| 46% | MONEY | 5 | "___ for Nothing," 1985 hit by Dire Straits which was one of the first music videos to feature computer-animated human figures |