| 100% | BUFFALOBILL | 11 | One of the first two ''American superstars,'' per 34 Across' book |
| 100% | ANNIEOAKLEY | 11 | One of the first two ''American superstars,'' per 34 Across' book |
| 49% | ANGELS | 6 | One of the first two MLB expansion teams |
| 47% | WASHINGTON | 10 | One of the first two states to permit marijuana for recreational use |
| 47% | COLORADO | 8 | One of the first two states to permit marijuana for recreational use |
| 46% | OMAR | 4 | Ilhan ___, one of the first two Muslim women elected to Congress |
| 45% | OMAR | 4 | Minnesotan Ilhan who is one of the first two Muslim women elected to Congress |
| 44% | TENZINGNORGAY | 13 | Sherpa who was one of the first two people to conquer Mount Everest: 2 wds. |
| 44% | EDMUNDHILLARY | 13 | New Zealand mountaineer who was one of the first two people to conquer Mount Everest: 2 wds. |
| 43% | JAMESMONROE | 11 | One of the first five 49-Acrosses |
| 43% | JOHNADAMS | 9 | One of the first five 49-Acrosses |
| 43% | THOMASJEFFERSON | 15 | One of the first five 49-Acrosses |
| 42% | ECUADOR | 7 | One of the only two South American countries that doesn't border Brazil |
| 42% | PASSENGER | 9 | One of two Cormac McCarthy books in 2022, The __ |
| 41% | ELSA | 4 | One of two Disney characters singing "For the First Time in Forever" |
| 40% | OLDS | 4 | One of the first automakers |
| 40% | APOSTLE | 7 | One of the first disciples |
| 40% | CREE | 4 | One of the First Nations |
| 40% | ADAM | 4 | One of the first mates |
| 40% | PAULMCCARTNEY | 13 | One of the two singers on 15-Across: 2 wds. |
| 39% | STAMBERG | 8 | Susan who was one of the "Founding Mothers of NPR," per a 2021 book by Lisa Napoli |
| 39% | INCA | 4 | One of the first potato farmers |
| 39% | SAUL | 4 | Israel’s first king, per the Book of Samuel |
| 39% | CREE | 4 | One of the First Nations of Canada |
| 39% | AOL | 3 | One of the first Internet service providers |
| 39% | TRACY | 5 | "Dick ___," one of the longest-running American comic strips which was first published in October 1931 |
| 39% | AISFORALIBI | 11 | Title of the first book in the 17-Across series |
| 38% | CHATROOM | 8 | One of the first ways to communicate online |
| 38% | COBB | 4 | One of the first five inductees at Cooperstown |
| 38% | SIT | 3 | One of the first commands a puppy learns |