| 100% | SHAZAM | 6 | One of the many exclamations improvised by Tobey Maguire when Spider-Man tries web-shooting for the first time |
| 34% | DOOM | 4 | First-person shooter game released in 1993 by id Software which is considered to be one of the most influential video games of all time |
| 32% | POI | 3 | Food that many Hawaii visitors try there for the first time |
| 30% | EYRE | 4 | "Jane ___," a novel by Charlotte Bronte that has become one of the most famous novels of all time |
| 30% | RPG | 3 | One of many played on the web series Dimension 20, for short |
| 30% | ZHIVAGO | 7 | "Doctor ___," one of the ten highest-grossing films of all time when adjusted for inflation |
| 30% | CAN | 3 | Warhol painted one of these 32 times for his first one-man gallery exhibition in the Ferus Gallery in 1962 |
| 29% | MINI | 4 | ___ skirt, short fashion of the 2000s, rocked by Britney Spears in "...Baby One More Time" |
| 29% | EATMYSHORTS | 11 | Catchphrase improvised by Nancy Cartwright for the first time on 28-Across (3 wds.) |
| 29% | NEWDADS | 7 | Ones taking paternity leave for the first time |
| 29% | FIG | 3 | One of the first fruits cultivated by humans |
| 28% | MONEY | 5 | "___ for Nothing," 1985 hit by Dire Straits which was one of the first music videos to feature computer-animated human figures |
| 28% | DISCOVERCOD | 11 | Try a North Atlantic fish for the first time? |
| 28% | DISCOVERY | 9 | The act of finding something for the first time |
| 28% | AHA | 3 | Cry when seeing something for the first time |
| 28% | DAUMIER | 7 | One of the most important men in modern art, per Baudelaire |
| 28% | ESTRAGON | 8 | One of the men waiting for Godot |
| 28% | ELSA | 4 | One of two Disney characters singing "For the First Time in Forever" |
| 27% | IBIS | 4 | One of the first birds released by Noah after the flood, in legend |
| 27% | POI | 3 | Food that tourists in Hawaii often try for the first time |
| 27% | SOSA | 4 | Sammy ___, one of the most famous Baseball players of all time |
| 27% | COEDS | 5 | Some University of Virginia undergrads in 1969, for the first time |
| 27% | ANEW | 4 | Once more as if for the first time, a fresh go |
| 27% | SKI | 3 | Equipment for one of the most popular winter sports on snow |
| 27% | ALDRIN | 6 | One of the first men on the moon, Buzz |
| 27% | VLADIMIR | 8 | One of the men waiting in "Waiting for Godot" |
| 27% | LITUP | 5 | First thing many have done when they've taken one of those ten minute breaks outside the back door in zero degree weather |
| 27% | LUAU | 4 | Party where tourists in Hawaii might try poi for the first time |
| 27% | RADNER | 6 | One of the original Not Ready for Prime Time Players |
| 27% | NOAH | 4 | Most popular boy's name in 2013, demoting Jacob for the first time since 1999 |