| 100% | OSHA | 4 | Org. concerned with the use of protective gear on job sites |
| 37% | NASA | 4 | Org. with an Astronomy Picture of the Day site |
| 36% | NSTA | 4 | Arlington, VA org. with position statements on The Teaching of Evolution and Responsible Use of Live Animals |
| 35% | EPA | 3 | Org. concerned with the AQI |
| 34% | ABSORBENTMINDED | 15 | Concerned with the quality of paper towels? |
| 34% | FAA | 3 | Org. concerned with the correct approach |
| 34% | EPA | 3 | Org. concerned with the ozone layer |
| 34% | SPACESCIENCE | 12 | The use of Rover on Mars, for example |
| 33% | SALEM | 5 | Capital of the only state with a two-sided flag using different designs on each side |
| 33% | ORAL | 4 | Needs the use of mouth, as with medicines |
| 33% | HISTORICAL | 10 | Concerned with events of the past |
| 32% | PEARL | 5 | With 4 Down, site of the attack that on today's date in 1941 lead to the US entering WWII |
| 32% | OSHA | 4 | Agency concerned with the well-being of employees: Abbr. |
| 32% | PENALCODE | 9 | Laws concerned with the punishment of crime |
| 32% | IRS | 3 | Org. with the goods on Capone |
| 31% | EZRA | 4 | Book concerned with the end of the Babylonian captivity |
| 31% | AMA | 3 | Org. with the Rod of Asclepius in its logo |
| 31% | EPA | 3 | Org. with the Office of Land and Emergency Management |
| 31% | ICER | 4 | One with the job of decorating cakes |
| 31% | EMT | 3 | One concerned with matters of the heart: Abbr. |
| 31% | ASSETMANAGER | 12 | Adviser concerned with the starts of 20-, 31- and 44-Across |
| 30% | NASA | 4 | Org. with the motto "For the benefit of all" |
| 30% | ISLAM | 5 | Religion with the holy sites of Mecca and Medina |
| 30% | ABOUT | 5 | On the topic of, concerning |
| 30% | POET | 4 | Person concerned with rhyme quite a bit of the time |
| 30% | ASPCA | 5 | Org. with the equine-adoption Web site My Right Horse |
| 30% | RAF | 3 | Mil. org. where the motto of "Per ardua ad astra" has been used on the badge since 1918 |
| 30% | MAT | 3 | Protective item on the floor of a car |
| 30% | BUMPERS | 7 | Protective guards on the front/rear of vehicles |
| 30% | BARCELONA | 9 | With 44-Down, site of the 1992 Olympics |