| 100% | USAF | 4 | Org. featured in "Dr. Strangelove" |
| 64% | CDC | 3 | Org. featured in "Outbreak" |
| 64% | NORAD | 5 | Org. featured in "WarGames" |
| 63% | NASA | 4 | Org. featured in 16-Across |
| 63% | IRA | 3 | Org. featured in "Patriot Games" |
| 62% | NORAD | 5 | Org. featured in 1983's "WarGames" |
| 62% | THENFL | 6 | Org. featured in 2015's "Concussion" |
| 62% | DEA | 3 | Org. featured in TV's "Weeds" |
| 62% | USAF | 4 | Org. featured in "The Right Stuff" |
| 62% | CDC | 3 | Org. featured in 2011's "Contagion" |
| 61% | NASA | 4 | Org. featured in the movie "Hidden Figures" |
| 61% | UFW | 3 | Org. featured in 2014's "Cesar Chavez" |
| 60% | PGA | 3 | Org. featured in the documentary series "Full Swing" |
| 58% | NASCAR | 6 | Org. featured in "Talladega Nights: The Ballad of Ricky Bobby" |
| 57% | NASA | 4 | Space org. featured in "Hidden Figures" (Abbr.) |
| 57% | SFPD | 4 | Law enforcement org. featured in "Bullitt" |
| 57% | MENSA | 5 | Org. featured in the Simpsons episode "They Saved Lisa's Brain" |
| 57% | MPAA | 4 | Org. featured in the documentary "This Film Is Not Yet Rated" |
| 55% | NHL | 3 | Org. featuring the human-sized Ducks in the 100 Across clue |
| 55% | DRE | 3 | Dr. featured in 2015's "Straight Outta Compton" |
| 55% | AMA | 3 | Org. founded in 1847 by Dr. Nathan Smith Davis |
| 55% | SMERSH | 6 | Soviet counterintelligence org. featured in James Bond novels |
| 55% | ATOMICAGE | 9 | Period satirized in "Dr. Strangelove" |
| 51% | COLDWAR | 7 | It was satirized in "Dr. Strangelove" |
| 51% | ROLES | 5 | Sellers had three in "Dr. Strangelove" |
| 50% | PETERSELLERS | 12 | President Merkin Muffley portrayer in "Dr. Strangelove" |
| 49% | WYNN | 4 | Keenan ___ (Colonel "Bat" Guano portrayer in "Dr. Strangelove") |
| 47% | SILENTO | 7 | Feature in "People"? |
| 47% | PLEAT | 5 | Feature in fabric |
| 46% | KONG | 4 | Major in "Dr. Strangelove" who takes a ride on a bomb |