| 100% | MDA | 3 | Org. whose telethon was the first to be viewed globally via the internet in 1998 |
| 39% | MALAYSIA | 8 | Kuala Lumpur's country that was the first Asian country to host the Commonwealth Games in 1998 |
| 39% | DESPACITO | 9 | 2017 chart-topping hit whose YouTube video was the first to reach 3 billion views |
| 35% | SHALOMMEIRTOWER | 15 | Tel Aviv skyscraper that was the first to be built in the Mideast |
| 35% | BRITNEYSPEARS | 13 | Musician whose first single "... Baby one more time" topped the charts in 1998 when she was just 17 years old: 2 wds. |
| 34% | TOBACCO | 7 | Rolfe was the first to cultivate this in Virginia |
| 34% | TEQUILA | 7 | "___ Sunrise," 1998 film starring Mel Gibson and Michelle Pfeiffer...and whose first word is the primary liquor in 14a |
| 34% | USCG | 4 | Org. whose academy's motto in English is "The sea yields to knowledge" |
| 34% | STANMUSIAL | 10 | Slugger born November 21, 1920 whose number was the first to be retired by the St. Louis Cardinals (2 wds.) |
| 33% | ESA | 3 | Intl. org. that was the first to land a probe on a comet (2014) |
| 33% | TOBEY | 5 | Actor Maguire who was the first to play Spider-Man in movies |
| 33% | MILE | 4 | Roger Bannister was the first to run it in under four minutes |
| 33% | SCI | 3 | US org. founded in '73 whose stated mission is to "protect the freedom to hunt and to promote wildlife conservation" (abbr.) |
| 33% | FAA | 3 | Org. whose plans are up in the air? |
| 33% | FAA | 3 | Org. whose agenda is up in the air? |
| 33% | PALM | 4 | Co. that was the first to successfully market a PDA worldwide in 1997 |
| 33% | NBA | 3 | Org. in which Lusia Harris was the first woman officially drafted |
| 33% | INCISORS | 8 | Teeth that are typically the first to grow in |
| 33% | ALPHA | 5 | Generation ___, first to be born in the 21st century |
| 33% | CDC | 3 | Org. that was the successor to the Office of Malaria Control in War Areas |
| 33% | FIDELIO | 7 | Opera whose name is the password to the secret party in Eyes Wide Shut |
| 33% | TMZ | 3 | Hollywood website that was the first to report Michael Jackson's death in 2009 |
| 32% | ALEKSEI | 7 | Leonov who was the first man to walk in space |
| 32% | DICKBUTTON | 10 | *Olympic champion who, in 1948, was the first to land a double axel in competition |
| 32% | ISABELWILKERSON | 15 | "Caste" author who was the first Black woman to win the Pulitzer Prize in journalism |
| 32% | INC | 3 | Business magazine that, in 1981, was the first to feature Steve Jobs on its cover |
| 32% | PGA | 3 | Babe Zaharias was the first woman to compete on its tour, in brief |
| 32% | CIA | 3 | Org. whose HQ is home to the unsolved puzzle sculpture Kryptos |
| 32% | MASSACHUSETTS | 13 | State whose General Court was the first to recognize Fourth of July as a state celebration |
| 32% | JACOBY | 6 | Ellsbury who was the first Native American of Navajo descent to play in Major League Baseball |