| 100% | NASA | 4 | Org. with programs that are taking off? |
| 45% | IPADS | 5 | Devices that might be awkward to take selfies with |
| 43% | AVIATOR | 7 | One whose idea may be taking off |
| 42% | SELFIE | 6 | Pic that might be taken with a stick |
| 42% | SELFIE | 6 | Photo that might be taken with a stick |
| 42% | MOON | 4 | "Fly Me to the ___," Frank Sinatra melody that was closely associated with NASA's Apollo space program |
| 41% | DIET | 4 | Routine food that is taken |
| 41% | STOLE | 5 | Took off with |
| 41% | ADORE | 5 | Be taken with |
| 41% | AIRMAN | 6 | One whose business is taking off? |
| 41% | AIRWOMAN | 8 | Her idea may be taking off |
| 41% | NUDIE | 5 | Movie whose genre is taking off? |
| 41% | STRIPPER | 8 | One whose business is taking off? |
| 41% | TEES | 4 | Shots are taken off of them |
| 41% | COURSES | 7 | Subjects that are taken in college |
| 41% | WAY | 3 | Path or route that is taken |
| 41% | UBER | 4 | App that will take you places |
| 41% | THETONIGHTSHOW | 14 | Long-running NBC program that was hosted by Johnny Carson when 58-Across made a guest appearance with his mother, Gloria Vanderbilt (3 wds.) |
| 41% | BOOKS | 5 | Takes off, with "it" |
| 40% | ORAL | 4 | Like medications that are taken by mouth |
| 40% | ORAL | 4 | Like vaccines that are taken by mouth |
| 40% | STOLEN | 6 | Like goods that are taken without permission |
| 40% | DRY | 3 | Ready to be taken off the clothesline |
| 40% | TITHE | 5 | Tenth part, that is taken as tribute |
| 40% | ROOK | 4 | New recruit that is taken from castle |
| 40% | BOA | 3 | Snake that will take your breath away |
| 40% | TORCHWOOD | 9 | 2006-2011 sci-fi program that is a spin-off, and an anagram, of 15-Across |
| 40% | PEEL | 4 | Take off fast, with "out" |
| 39% | STRIPSHOW | 9 | Performance by one whose career is taking off |
| 39% | HAT | 3 | It might be taken off to show respect |