| 100% | SNL | 3 | Originator of parody ads for 5-hour Empathy and Tylenol BM, in brief |
| 28% | BIO | 3 | Mine, in brief, includes "cruciverbalist" and "mathematician" for example |
| 27% | COCOCHANEL | 10 | French fashion designer and namesake of the brand that was founded in 1909 and is known for its perfume No. 5: 2 wds. |
| 27% | JAMESFRANCO | 11 | American actor pursuing an English PHD at Yale with a reported IQ of 130, and known for his role in "127 Hours": 2 wds. |
| 26% | NOPE | 4 | Briefer version of "Not for all the tea in China!" |
| 26% | JOHNNYENGLISH | 13 | A comically incompetent spy for "MI7," created as a parody of 50a, and portrayed by Rowan Atkinson in the films by the same name: 2 wds. |
| 26% | SCENE3 | 6 | Final part of Act 5 in "Romeo and Juliet" |
| 26% | POSEY | 5 | Parker of “Waiting for Guffman” and “Best in Show” |
| 26% | WHITER | 6 | Word in ads for toothpaste and detergent |
| 26% | NEWSHOLE | 8 | Space in a paper available for journalism instead of ads |
| 26% | DST | 3 | Reason for losing an hour of sleep in March (Abbr.) |
| 26% | ALPS | 4 | Locale for car chases in "Goldfinger" and "Quantum of Solace" |
| 25% | DIGESTIVE | 9 | System of organs for food in and out of a body |
| 25% | MILKTEETH | 9 | They grow in for babies and fall out around age 5 |
| 25% | PTA | 3 | Teachers and parents in cooperation for betterment of a school (abbr) |
| 25% | LASVEGASSTRIP | 13 | Stretch of road in Nevada known for gambling and resort hotels |
| 25% | ANTAEUS | 7 | Son of Poseidon and Gaia in Greek mythology noted for his strength |
| 25% | SNL | 3 | Source of ads for Baby Spanx and the Love Toilet |
| 24% | NEWFOREST | 9 | Region of woodland and heath in Hampshire and Wiltshire noted for its ponies |
| 24% | NEWT | 4 | "Eye of ___ and toe of frog ... " (cauldron ingredients for the Witches in "Macbeth") |
| 24% | COSMO | 5 | Carrie Bradshaw's choice of cocktail in "Sex and the City," for short |
| 24% | OYER | 4 | Court of ___ and Terminer, as created for the Salem witch trials in 1692 |
| 24% | SORGHUM | 7 | Genus of flowering plants in the grass family grown for grain and fodder |
| 24% | RBI | 3 | One of 2,297 for Hank Aaron, in brief |
| 24% | IRA | 3 | Bit of financial planning for old age, in brief |
| 24% | BDAY | 4 | Cause for cake and candles, in brief |
| 24% | ALTROCK | 7 | Genre for Beck and Nirvana, in brief |
| 24% | MANBOOKERPRIZE | 14 | Award won by Marlon James, in 2015, for “A Brief History of Seven Killings” |
| 24% | REYNOLDS | 8 | Burt ___, winner of a 1993 Razzie for his role in "Cop and a Half" |