| 100% | RABBI | 5 | Osnat Barzani is thought by some to have been the first female one |
| 43% | BADROMANCE | 10 | 2009 song by Lady Gaga that made her the first female in British chart history to have three number-one singles in one year: 2 wds. |
| 43% | MEME | 4 | 1996's "Dancing Baby" might have been the first one to go viral |
| 42% | EROICA | 6 | Work considered by some to be the first Romantic-era symphony |
| 41% | ORR | 3 | He was the first hockey player to have 100 assists in one season |
| 40% | DOG | 3 | President Trump is the first president in over 100 years not to have one of these |
| 38% | STELLAMARIS | 11 | 2022 prequel to "The Passenger" that is the first novel by 34-Across to feature a female protagonist (2 wds.) |
| 38% | UNLUCKY | 7 | A black cat, thought by some to be __ |
| 38% | LYRIC | 5 | "In the town where I was born / Lived a man who sailed to sea" is the first one in "Yellow Submarine," by the Beatles |
| 37% | JOHNMADDEN | 10 | Football player turned broadcaster who was the first one to have worked for all of the "Big Four" TV networks: 2 wds. |
| 37% | DOOM | 4 | First-person shooter game released in 1993 by id Software which is considered to be one of the most influential video games of all time |
| 36% | WIN | 3 | Be the first one to finish a race, say |
| 36% | ILL | 3 | "___ be the first one to finish the assignment." |
| 36% | PACMAN | 6 | One of the most popular arcade games in the world, where the player has to avoid being eaten by the 4 ghosts: Hyph. |
| 36% | STEPFORMAN | 10 | "One small ____, one giant leap for mankind," what 31a was initially thought to have said upon landing on the Moon: 3 wds. |
| 36% | GODS | 4 | "Men Like ___," 1923 novel by H.G. Wells that was one of the first to feature the idea of parallel universes |
| 36% | MONEY | 5 | "___ for Nothing," 1985 hit by Dire Straits which was one of the first music videos to feature computer-animated human figures |
| 36% | ARAMAIC | 7 | Language thought to have been spoken by Jesus |
| 36% | JESUIT | 6 | Francis is the first pope to be one |
| 36% | MASON | 5 | Elizabeth Aldworth was the first recorded female one |
| 36% | EMAIL | 5 | Clinton was the first president to send one |
| 36% | AMELIA | 6 | Earhart who was the first female aviator to fly solo across the Atlantic |
| 36% | SPORTSCENTER | 12 | Ronda Rousey was the first female athlete to guest-host this ESPN show |
| 36% | SAINT | 5 | Ulrich was the first one created by a pope |
| 36% | EROICA | 6 | Work some consider to be the first Romantic symphony |
| 36% | KATYPERRY | 9 | "Roar" singer with more than 42 million YouTube subscribers who was the first artist to have multiple music videos reach one billion views on YouTube (2 wds.) |
| 35% | AIMEEMANN | 9 | Grammy award winning female bassist who has been named one of the world's top ten greatest living songwriters by NPR: 2 wds. |
| 35% | THOUSAND | 8 | This is the first number to have the letter "A" |
| 35% | MANX | 4 | Breed once thought by some to be a cross between a cat and a rabbit |
| 35% | JET | 3 | The Lippisch Ente was the first one of these to fly, in 1928 |