| 100% | SARS | 4 | Outbreak in early-two-thousands news |
| 63% | SARS | 4 | Disease in an early-two-thousands outbreak, familiarly |
| 55% | MURSE | 5 | Man bag, in early-two-thousands slang |
| 52% | ITEM | 4 | Two in the news |
| 52% | ITEMS | 5 | Twos in the news |
| 52% | PIMPED | 6 | Souped up, as one’s ride, in early-two-thousands slang |
| 50% | ITEM | 4 | Two stars in the news, perhaps |
| 50% | NASCARDADS | 10 | Largely white and rural set of voters, in early-two-thousands political analysis |
| 46% | TECHBUBBLE | 10 | It burst in the early two-thousands and sent dot-com stocks tumbling |
| 43% | MEME | 4 | Image with two lines of Impact font, in the early days |
| 43% | YWCA | 4 | Grp. that opened an early employment bureau in New York City |
| 43% | PHAT | 4 | Baby ___ (prominent fashion brand of the early two-thousands) |
| 42% | BOHO | 4 | ___-chic (hippie-inspired fashion trend of the early two-thousands) |
| 42% | THEOC | 5 | Two-thousands Fox drama set in Newport Beach |
| 40% | ONETON | 6 | Two thousand pounds |
| 40% | TON | 3 | Two thousand pounds |
| 40% | AGO | 3 | In earlier times |
| 40% | AGO | 3 | In earlier time |
| 40% | SARS | 4 | Early-two-thousands pandemic |
| 40% | TONS | 4 | Two thousand pounds, plural |
| 39% | REBA | 4 | McEntire who had an eponymous sitcom in the early two-thousands |
| 39% | DRAKE | 5 | Rapper and superfan of 32-Across who released two new songs in honor of their championship |
| 38% | AOL | 3 | Co. involved in a major merger of the early two-thousands |
| 38% | PRESEAT | 7 | Usher in early |
| 38% | LADAS | 5 | New cars that will save you 20 to 50 thousand rubles in June, if you have a trade in |
| 38% | EBERT | 5 | His obituary in the New York Daily News began with the line "He got two thumbs up" |
| 38% | LAFITTE | 7 | Jean ___, French pirate who operated in the Gulf of Mexico near New Orleans in the early 1800s |
| 38% | MLII | 4 | A thousand and fifty-two, in Roman numerals |
| 38% | SEXANDTHECITY | 13 | Whence the line “Women come to New York in search of the two Ls: labels and love” |
| 38% | TON | 3 | About two thousand pounds |