| 100% | MARIOBROS | 9 | Pair of plumbers, one of whom first appeared in "Donkey Kong" |
| 50% | RAISIN | 6 | Agatha —, fictional creation of M C Beaton who first appeared in a 1992 mystery novel |
| 50% | NANCYDREW | 9 | Character who first appeared in "The Secret of the Old Clock" |
| 49% | TWEETYBIRD | 10 | Cartoon canary who first appeared in 1942's A Tale of Two Kitties |
| 49% | INSPECTORBUCKET | 15 | “Bleak House” character who was one of the first detectives in English fiction |
| 49% | PERRYMASON | 10 | Lawyer creation of Erle Stanley Gardner who first appeared in 1933 novel The Case of the Velvet Claws |
| 48% | PERRY | 5 | & 25A Lawyer creation of Erle Stanley Gardner who first appeared in 1933 novel The Case of the Velvet Claws |
| 48% | CHAN | 4 | Charlie —, detective creation of Earl Biggers who first appeared in The House Without a Key |
| 47% | DUPIN | 5 | C Auguste —, detective creation of Edgar Allan Poe who first appeared in 1841’s The Murders in the Rue Morgue |
| 47% | DUPIN | 5 | C Auguste —, detective creation of Edgar Allan Poe who first appeared in 1841's The Murders in the Rue Morgue |
| 47% | TWEETY | 6 | Animated yellow canary seen in "Looney Tunes" who first appeared in "A Tale of Two Kitties" |
| 47% | HUCKLEBERRY | 11 | ___ Finn, a fictional character who first appeared in 51a and is a friend of the protagonist |
| 47% | DOCSAVAGE | 9 | Fictional character created by Lester Dent who first appeared in 1933 pulp novel The Man of Bronze |
| 47% | CAMPION | 7 | Albert —, detective creation of Margery Allingham who first appeared in 1929 novel The Crime At Black Dudley |
| 47% | CHAN | 4 | Charlie —, detective creation of Earl Biggers who first appeared in 1925 novel The House Without a Key |
| 46% | NANCYDREW | 9 | Fictional girl detective who first appeared in 1930 novel The Secret of the Old Clock by Carolyn Keene |
| 45% | KASPAR | 6 | & 17A German foundling, subject of a stage play by Peter Handke, who first appeared in Nuremberg market place in 1828 |
| 45% | HOPPER | 6 | Scientist and naval officer Grace ___ who was one of the first three pioneers in computer programming |
| 45% | OONA | 4 | Actress Chaplin who appeared in the first season of "Game of Thrones" |
| 44% | LIZAMINNELLI | 12 | "Cabaret" star and singer who won one of the first Grammy Legend Awards, in 1990: 2 wds. |
| 44% | SMOKEYROBINSON | 14 | "I Second That Emotion" singer who won one of the first Grammy Legend Awards, in 1990: 2 wds. |
| 44% | WILLIENELSON | 12 | "Always on My Mind" singer who won one of the first Grammy Legend Awards, in 1990: 2 wds. |
| 44% | ANNEHATHAWAY | 12 | "Interstellar" actress who appears in one of the stories on 27-Across (2 wds.) |
| 44% | KENDALLJENNER | 13 | World's highest-paid model as of 2017, who first appeared in a reality TV show with her famous half-sisters: 2 wds. |
| 43% | NORMAN | 6 | ___ Osborn, supervillain who is the best-known incarnation of Green Goblin and first appeared in "The Amazing Spider-Man" |
| 43% | JOHNSLATTERY | 12 | "Mad Men" actor who appears in one of the stories on 27-Across (2 wds.) |
| 43% | IDA | 3 | ___ B. Wells, civil-rights leader who founded one of the first Black women’s suffrage groups in the U.S. |
| 43% | THOR | 4 | Superhero with a hammer who appeared in the first issue of the comic book "The Avengers" |