| 100% | PENN | 4 | Pennsylvania founder Sir William __ |
| 53% | PENN | 4 | William —, English Quaker who founded the Province of Pennsylvania in North America |
| 51% | OSLER | 5 | Sir William, physician who co-founded Johns Hopkins Hospital |
| 49% | OSLER | 5 | Canadian physician Sir William |
| 49% | OSLER | 5 | Medical pioneer Sir William |
| 49% | PARRY | 5 | Arctic explorer sir william |
| 47% | OSLER | 5 | Canadian physician Sir William ___ |
| 47% | OSLER | 5 | Sir William ___, medical pioneer |
| 46% | OSLER | 5 | Physician Sir William |
| 44% | BEECHAM | 7 | London Philharmonic founder Sir Thomas ___ |
| 43% | HUGGINS | 7 | Victorian English astronomer Sir William |
| 43% | OSLER | 5 | Sir William ___, so-called "Father of Modern Medicine" |
| 41% | BRIG | 4 | Nancy, in a Sir William Gilbert song |
| 41% | YMCA | 4 | Sir George Williams's org. |
| 41% | GAINES | 6 | William who founded Mad magazine |
| 41% | DANFORTH | 8 | William ___, who founded Ralston Purina |
| 40% | OSLER | 5 | Sir William who wrote "The Principles and Practice of Medicine" |
| 40% | OSLER | 5 | Sir William ___, physician often called the father of modern medicine |
| 40% | RAFFLES | 7 | Founder of London Zoo, Sir Stamford __ |
| 40% | EPONYM | 6 | William Penn for Pennsylvania, e.g. |
| 40% | MAD | 3 | William Gaines founded it in 1953 |
| 39% | ONEIL | 5 | William ___, founder of Investor's Business Daily |
| 39% | SERENA | 6 | Williams sister who wed Reddit founder Ohanian |
| 39% | HARRAH | 6 | Casino chain founder William F. ___ |
| 39% | DILLARD | 7 | Department store founder William T. |
| 37% | BETHLEHEM | 9 | Famous city also found in Pennsylvania |
| 37% | SINGAPORE | 9 | Country founded by Sir Stamford Raffles |
| 37% | MAD | 3 | Magazine William Gaines founded in 1952 |
| 37% | PENN | 4 | 17th-century William who founded Philadelphia |
| 37% | OTIS | 4 | Singer Williams who founded the Temptations |