| 100% | CARUSO | 6 | Performer in the first U.S. public radio broadcast, 1910 |
| 65% | ENRICO | 6 | Caruso who was featured on the first public-radio broadcast in the U.S., in 1910 |
| 43% | IKE | 3 | Nickname of the first U.S. president born in 7-Down |
| 42% | SOVIET | 6 | The first "S" in U.S.S.R. |
| 42% | SEE | 3 | Word in the first line of the U.S. national anthem |
| 42% | RADIO | 5 | In 1922, Warren G. Harding became the first U.S. president to be broadcast over this |
| 40% | PBS | 3 | Leading public broadcast service in the US |
| 40% | ZOO | 3 | Philadelphia had the first one in the U.S. (1874) |
| 40% | YALE | 4 | College that awarded the first Ph.D. in the U.S. |
| 40% | YALE | 4 | University that awarded the first Ph.D. in the U.S. |
| 39% | YMCA | 4 | The first US one opened in Boston in 1851 |
| 39% | BOAC | 4 | Airline mentioned in the first line of the Beatles' "Back in the U.S.S.R." |
| 39% | SOVIET | 6 | The first S in USSR |
| 39% | RPI | 3 | Sch. that awarded the first civil engineering degree in the U.S. |
| 39% | STU | 3 | Rasmussen who was the first openly transgender mayor in the U.S. |
| 39% | TCCHEN | 6 | Scorer of the first double eagle in U.S. Open history, 1985 |
| 39% | WARRENGHARDING | 14 | U.S. president who, in 1922, became the first president to have his voice transmitted on the radio (3 wds.) |
| 39% | BRITISH | 7 | It's the first B in broadcasting company BBC |
| 39% | OBERLIN | 7 | Ohio college that was the first in the U.S. to admit women |
| 38% | OBAMA | 5 | First president not born in the continental U.S. |
| 38% | OBERLIN | 7 | First coeducational college in the U.S. |
| 38% | SELF | 4 | The first "S" in S.A.S.E. |
| 38% | SOV | 3 | The first "S" in S.S.R.: Abbr. |
| 38% | OBERLIN | 7 | Ohio college that was the first in the U.S. to award degrees to women |
| 37% | LAPD | 4 | First law enforcement org. in the U.S. to hire a female officer (1910) |
| 37% | CENTRAL | 7 | Alphabetically first time zone in the contiguous U.S. |
| 37% | DAYTIMEMEAWARDS | 15 | Prizes won by Acadia National Park for the first sight of sunrise in the U.S.? |
| 37% | BLACKWELL | 9 | Elizabeth, the first female doctor in the US |
| 37% | RPI | 3 | First private engineering school in the U.S. |
| 37% | PHILLISWHEATLEY | 15 | First Black published poet in the U.S. |