| 100% | LEONA | 5 | Physicist Woods who was the only women on Enrico Fermi's team that built the first nuclear reactor |
| 40% | FERMI | 5 | Enrico ___, Italian physicist who is known for creating the world's first nuclear reactor and has an element named after him |
| 34% | COLBERT | 7 | Comedian who was the only man on Maxim's 2012 Hot 100 list of most beautiful women |
| 34% | FERMI | 5 | Enrico —, Italian nuclear physicist who headed the group that produced the first controlled nuclear reaction |
| 32% | DOMEE | 5 | Shi who was the first woman to have the sole director’s credit on a Pixar feature, for “Turning Red” |
| 31% | KIMMULKEY | 9 | Coach of 41-Across who is the only coach in women's college basketball to win national championships with two teams (2 wds.) |
| 31% | KIMMULKEY | 9 | Coach of the 40-Across who is the only coach in women's college basketball to win national championships with two teams (2 wds.) |
| 31% | ELAYNE | 6 | Boosler who was the first woman to have an hour-long comedy special on cable TV |
| 30% | RETTON | 6 | Gymnast Mary Lou who was the first woman to appear on the front of a Wheaties box |
| 30% | TYRA | 4 | Banks who was the first African-American woman on the cover of GQ |
| 30% | MARIAHCAREY | 11 | Five-time Grammy winner who is the only artist whose first five singles reached #1 on the Billboard Hot 100 (2 wds.) |
| 30% | TYRA | 4 | Banks who was the first African-American woman featured on the cover of "GQ" |
| 30% | SAHL | 4 | Satirist who said "If you were the only person left on the planet, I would have to attack you. That's my job" |
| 30% | ELANA | 5 | ___ Meyers, who in 2015 was part of the first world champion team from the US in women's bobsled |
| 30% | JOANRIVERS | 10 | Comedian who was the first woman to host a late-night talk show on a major network: 2 wds. |
| 30% | SAHL | 4 | Political satirist who said "If you were the only person left on the planet, I would have to attack you. That's my job" |
| 29% | ATOMICPILE | 10 | The first one of these was built by Fermi and his team in 1942 |
| 29% | ALICIAKEYS | 10 | "Girl on Fire" singer/pianist who was the first woman to have an "MTV Unplugged" album debut at #1 (2 wds.) |
| 29% | RENO | 4 | Janet who was the first woman to serve as U.S. attorney general |
| 29% | REBECCALOBO | 11 | Center on UConn's 1995 undefeated women's team who will be inducted into the Basketball Hall of Fame today: 2 wds |
| 29% | ASUKA | 5 | Female wrestler seen on WWE who was the second Women's Grand Slam Champion |
| 28% | ADLER | 5 | Irene who was the only woman to outwit Sherlock Holmes |
| 28% | LUSIA | 5 | ___ Harris, former WNBA player who was the first and only woman ever to be officially drafted by the NBA |
| 28% | EFFA | 4 | Manley who is the only woman in the Baseball Hall of Fame |
| 28% | BART | 4 | Simpson who was the only fictional character on Time's 100 Most Important People of the 20th Century list |
| 28% | IDA | 3 | Lupino who was the only woman to direct an episode of the 1959 The Twilight Zone series |
| 28% | NAOMAMPBELL | 11 | *Woman who was the first Black model to appear on the cover of Time |
| 27% | EILEEN | 6 | Collins who was the first woman Space Shuttle commander |
| 27% | NEIL | 4 | Armstrong who was the first person on the moon |
| 27% | ARENA | 5 | Friends ___ (Stockholm venue that was the first stop on Beyoncé’s Renaissance World Tour) |