| 100% | PHILDONAHUE | 11 | Pioneering daytime talk-show host who was a 2024 recipient of the Medal of Freedom: 2 wds. |
| 66% | MEDGAREVERS | 11 | Civil rights activist who was a posthumous recipient of the Presidential Medal of Freedom in 2024: 2 wds. |
| 59% | ELLENDEGENERES | 14 | Daytime talk show host who is a vegan: 2 wds. |
| 59% | MICHELLEYEOH | 12 | Oscar-winning star of "Everything Everywhere All at Once" who was a 2024 Medal of Freedom recipient: 2 wds. |
| 55% | MILTONBERLE | 11 | Early TV variety show host who was a charter inductee into the Television Hall of Fame: 2 wds. |
| 51% | JIMMYKIMMEL | 11 | Late-night talk show host who hosts the prime-time game show "Who Wants to Be a Millionaire": 2 wds. |
| 51% | ROSIEODONNELL | 13 | Host of a self-titled talk show who hosted the 1999 and 2000 Grammy ceremonies: 2 wds. |
| 51% | ROSIEODONNELL | 13 | American TV presenter and activist who has hosted several daytime television talk shows and was a moderator on "The View": 2 wds. |
| 50% | ELLEN | 5 | ___ DeGeneres who is the recipient of a Presidential Medal of Freedom |
| 49% | JIMMYKIMMEL | 11 | Talk show host who recently hosted the Oscars for the second year in a row: 2 wds. |
| 49% | JOANRIVERS | 10 | Comedian who was the first woman to host a late-night talk show on a major network: 2 wds. |
| 49% | JAMESCORDEN | 11 | English late night show host who was the co-creator of BBC's Gavin & Stacey: 2 wds. |
| 49% | RICHARDDAWSON | 13 | "Family Feud" host who was a regular panelist on the 1970s version of "Match Game": 2 wds. |
| 49% | OPRAHWINFREY | 12 | TV talk show host who received the NAACP's Spingarn Medal in 2000: 2 wds. |
| 48% | CHRISHARRISON | 13 | Host of the game show "Who Wants to Be a Millionaire": 2 wds. |
| 48% | STEPHENCOLBERT | 14 | Host of "The Late Show" who was once a correspondent on "The Daily Show": 2 wds. |
| 48% | JOHNOLIVER | 10 | Host of "Last Week Tonight" who was once a correspondent on "The Daily Show": 2 wds. |
| 47% | DONALDTRUMP | 11 | "The Apprentice" host who was the honoree of a 2011 Comedy Central roast: 2 wds. |
| 47% | MARIEOSMOND | 11 | Singer and talk show host who has been a spokesperson for Nutrisystem: 2 wds. |
| 47% | RISEANDSHINE | 12 | 43-Across novel about a morning talk show host who is fired because of an on-air gaffe (3 wds.) |
| 47% | JIMMYKIMMEL | 11 | American late night show host who was the co-host of Comedy Central's "The Man Show": 2 wds. |
| 46% | ISABELALLENDE | 13 | Chilean-American writer who was awarded the 2014 Presidential Medal of Freedom: 2 wds. |
| 46% | KELLIEPICKLER | 13 | Former "American Idol" contestant who's hosting a new daytime talk show with Ben Aaron: 2 wds. |
| 46% | DONALDTRUMP | 11 | "The Apprentice" host who was the subject of a Comedy Central Roast in 2011: 2 wds. |
| 45% | ELLENDEGENERES | 14 | Talk show host and star of a 1990s ABC sitcom, whose title was her first name: 2 wds. |
| 45% | PHILDONAHUE | 11 | Husband of 13-Across who won nine Emmys for hosting his daytime talk show: 2 wds. |
| 45% | ITZHAKPERLMAN | 13 | Tel Aviv-born violinist who was awarded the Presidential Medal of Freedom in 2015: 2 wds. |
| 44% | DOLORESHUERTA | 13 | Civil rights leader, played by Rosario Dawson in the 18-Across biopic, who received a Presidential Medal of Freedom in 2012: 2 wds. |
| 44% | GEORGELOPEZ | 11 | Talk show host who plays a teacher in "Spare Parts": 2 wds. |
| 44% | DREWBARRYMORE | 13 | "The Wedding Singer" actress who has hosted a daytime television talk show since 2020 (2 wds.) |