| 100% | ORK | 3 | Planet in the 1978 American sci-fi sitcom "Mork & Mindy" about an extraterrerstrial who comes to Earth |
| 41% | SMALLWONDER | 11 | 1985 American sci-fi sitcom about the family of an engineer who creates a human girl-robot Vicki: 2 wds. |
| 34% | BUCK | 4 | "___ Rogers in the 25th Century," 1979 American sci-fi series about an astronaut who emerges out of suspended animation |
| 33% | BROOKLYN | 8 | Colm Tóibín novel about an Irish woman who moves to New York in the 1950s |
| 32% | THESOUTH | 8 | 1990 novel by 38-Across about an Irish woman who moves to Barcelona in the 1950s (2 wds.) |
| 31% | BROOKLYN | 8 | 2009 novel by 38-Across about an Irish woman who moves to New York in the 1950s (2 wds.) |
| 31% | DAWES | 5 | American gymnast Dominique who was the first Black athlete to win an Olympic gold medal in gymnastics |
| 31% | JETSONS | 7 | "The ___," animated sci-fi sitcom about space that revolves around a high-tech family who live in Orbit City |
| 30% | JIE | 3 | Author and dissident Yu ___, who came to the US in 2012 |
| 28% | JOHNGLENN | 9 | American who orbited the Earth in 1962, senator |
| 28% | RAF | 3 | “A Yank in the ___” (1941 film about an American war pilot) |
| 28% | QUANTUMLEAP | 11 | 1989 American sci-fi series about a physicist who leaps through spacetime to correct historical mistakes: 2 wds. |
| 28% | CROSSWORLDS | 11 | 1996 sci-fi film featuring Jack Black about a college student who holds the key to another dimension |
| 28% | MARS | 4 | Planet next to Earth in the solar system |
| 27% | UFO | 3 | Sci-fi film with Alex Sharp and Gillian Anderson about events at the Cincinnati Intl. Airport, released straight to video in 2018 |
| 27% | ORK | 3 | Home planet of Mindy's mate in an old sitcom |
| 27% | URBANAREA | 9 | Home to about 4 in 5 Americans, per the census |
| 27% | QUINCY | 6 | 2018 music documentary about an American musician who was nominated for the Grammy 80 times |
| 27% | ALTAIRIV | 8 | The planet in the sci-fi classic "Forbidden Planet" |
| 26% | LOSTINSPACE | 11 | Popular sci-fi TV series on Netflix based on the family of space colonists who crash-land on an unknown planet: 3 wds. |
| 26% | OLIVIAMUNN | 10 | The Daily Show correspondent who went on to star in an X-Men movie |
| 26% | TERRAFORM | 9 | Change a planet to resemble earth, as in many sci-fi novels |
| 26% | BOONE | 5 | Pat who co-starred in "Journey to the Center of the Earth" |
| 26% | LIN | 3 | Jeremy who was the first Asian American to win an NBA Championship |
| 26% | MICHAELPHELPS | 13 | US swimmer who came out of retirement in 2014 to swim at the Rio Olympics: 2 wds. |
| 26% | THOMSETT | 8 | Sally —, actress who played Jo in 1970s ITV sitcom Man About the House |
| 26% | LAIKA | 5 | Dog who became the first living being to orbit the Earth in 1957 |
| 26% | MARS | 4 | Red planet next to Earth in the Solar System |
| 26% | TORY | 4 | Term used in the American Revolution to describe those who remained loyal to the British Crown and government |
| 26% | EMILYINPARIS | 12 | Netflix series about an American woman who moves to France starring 14-Across and 29-Across (3 wds.) |