| 100% | AHSIN | 5 | Play co-authored by Mark Twain |
| 61% | ISHEDEAD | 8 | 1898 play by Mark Twain that opened on Broadway in 2007 |
| 56% | TOM | 3 | Sawyer created by Mark Twain |
| 54% | AHSIN | 5 | Mark Twain/Bret Harte play |
| 53% | SAWYER | 6 | "The Adventures of Tom ___," novel by Mark Twain |
| 52% | SAWYER | 6 | He appears in four novels by Mark Twain: Tom __ |
| 50% | KAPLAN | 6 | "Mr. Clemens and Mark Twain" author Justin |
| 50% | INJUNJOE | 8 | Villain in 1876 novel The Adventures of Tom Sawyer by Mark Twain |
| 49% | ORLEAN | 6 | Author played by Streep in ''Adaptation'' |
| 49% | HARD | 4 | ___-boiled, phrase meaning "tough and cynical" that was first used by Mark Twain |
| 48% | PUDDNHEAD | 9 | & 21A 1894 novel by Mark Twain set in the town of Dawson's Landing |
| 47% | EVESDIARY | 9 | Mark Twain tale narrated in the first person by a noted first woman |
| 45% | IRIS | 4 | Author Murdoch played onscreen by Kate Winslet and Judi Dench |
| 45% | ORLEAN | 6 | Author Susan played by Meryl Streep in 2002's "Adaptation" |
| 45% | ROUGHINGIT | 10 | 1872 semi-autobiographical work by Mark Twain describing his travels in Nevada, California and the Sandwich Islands |
| 44% | DOUBLE | 6 | "A ___ Barrelled Detective Story," short story by Mark Twain that was written as a parody of Sherlock Holmes |
| 44% | VAL | 3 | Kilmer who played Mark Twain |
| 43% | ISHE | 4 | "___ Dead?" (Mark Twain play) |
| 43% | HUCKLEBERRY | 11 | "Adventures of ___ Finn," satirical novel written by Mark Twain which is a direct sequel to the "Adventures of Tom Sawyer" |
| 42% | EARL | 4 | 17th ___ of Oxford, author of Shakespeare's plays, by some accounts |
| 42% | AHSIN | 5 | Bret Harte/Mark Twain play |
| 42% | VISION | 6 | Superhero co-created by 41-Across and played by Paul Bettany |
| 42% | FALCON | 6 | Superhero co-created by 41-Across and played by Anthony Mackie |
| 42% | ODETS | 5 | Clifford —, author of stage plays Waiting for Lefty and Clash by Night |
| 42% | JAMESBARRIE | 11 | "Peter Pan" author played by Johnny Depp in "Finding Neverland": 2 wds. |
| 41% | ODETS | 5 | Clifford —, author of the stage plays Waiting for Lefty and Clash by Night |
| 41% | DOGEARED | 8 | Marked Twain? |