| 100% | ARCHER | 6 | Popular adult animated sitcom created by Adam Reed about a dysfunctional spy agency |
| 38% | FUTURAMA | 8 | Popular animated sitcom created by Matt Groening about Earth in the year 3000 |
| 30% | BOBS | 4 | "___ Burgers," popular animated sitcom created by Loren Bouchard |
| 30% | RICKANDMORTY | 12 | Animated sitcom on Adult Swim about a mad scientist's escapades with his grandson: 3 wds. |
| 29% | PARK | 4 | "South ___," popular animated sitcom created by Trey Parker and Matt Stone |
| 29% | THESIMPSONS | 11 | Popular American animated sitcom by Matt Groening which is a satirical depiction of working-class life: 2 wds. |
| 29% | GUY | 3 | "___ Guy," animated sitcom created by Seth MacFarlane |
| 29% | BOBS | 4 | "___ Burgers," animated sitcom created by Loren Bouchard |
| 29% | GUY | 3 | "Family ___," American animated sitcom created by Seth MacFarlane |
| 26% | JETSONS | 7 | "The ___," animated sitcom produced by Hanna-Barbera which is about a family in the future |
| 24% | JETSONS | 7 | "The ___," Hanna-Barbera animated sitcom about a family in the future |
| 24% | ARRESTED | 8 | __ Development, sitcom about a dysfunctional family |
| 23% | BUFFY | 5 | 1997-2003 TV series about a vampire slayer created by Joss Whedon, for short |
| 23% | EASY | 4 | "Captain ___, Soldier of Fortune," comic strip about a Southern adventurer created by Roy Crane |
| 23% | RICK | 4 | "___ and Morty," popular American adult animated sci-fi sitcom by Justin Roiland and Dan Harmon |
| 23% | SCHITTSCREEK | 12 | Canadian sitcom created by 26-Across and his son Daniel that won a record seven Emmys in 2020 (2 wds.) |
| 23% | IDREAMOFJEANNIE | 15 | Sitcom created by Sidney Sheldon |
| 22% | AMERICANDAD | 11 | Fox's adult animated sitcom which was picked up by TBS after it was canceled post its eleventh season: 2 wds. |
| 22% | BUNHEADS | 8 | Freeform's comedy-drama series about a Las Vegas showgirl which was created by Amy Sherman- Palladino |
| 22% | ELAINEBENES | 11 | Character played by Julia Louis-Dreyfus in a sitcom about "nothing" (2 wds.) |
| 22% | FAMILYGUY | 9 | Animated Fox sitcom about the dysfunctional Griffins: 2 wds. |
| 22% | RICK | 4 | "___ and Morty," adult animated sitcom |
| 22% | STAN | 4 | Popular song by Eminem about a crazed fan, featuring Dido |
| 21% | ISPITONYOURGRAVY | 16 | Film about a dysfunctional Thanksgiving family? |
| 21% | BOJACKHORSEMAN | 14 | Netflix animated series about a washed-up sitcom star: 2 wds. |
| 21% | IGOR | 4 | 2008 animated film about a lab assistant, voiced by John Cusack |
| 21% | GUY | 3 | "Family ___," 1999 sitcom created by Seth MacFarlane |
| 21% | GUY | 3 | "Family ___" (1999 sitcom created by Seth MacFarlane) |
| 21% | FAMILYGUY | 9 | Animated sitcom about the Griffins |
| 21% | GILMOREGIRLS | 12 | The WB's (original network) AFI Award-winning series about a mother-daughter duo created by Amy Sherman- Palladino: 2 wds. |