| 100% | SIMS | 4 | Popular video game of 2000, with "The" |
| 67% | PAYNE | 5 | Max ___, popular video game series of the 2000s |
| 67% | PAYNE | 5 | Max ____, popular video game series of the 2000s |
| 63% | SEGA | 4 | Company with the Streets of Rage video game franchise |
| 63% | SIMS | 4 | Popular video game series, with "The" |
| 60% | MARIOBROS | 9 | Video game franchise with characters found at the ends of 17-, 20-, 53- and 58-Across |
| 60% | DONKEYKONG | 10 | Video game with a gorilla that first featured the main character of 43-Across (2 wds.) |
| 56% | GTA | 3 | Popular video game series with cars, for short |
| 54% | RASH | 4 | "Road ___," popular bike racing video game of the 90's |
| 54% | AAA | 3 | Video game with the highest development budget |
| 53% | MSPACMAN | 8 | Female protagonist in a video game of the same name |
| 53% | HALO | 4 | Video game series with the protagonist Master Chief |
| 53% | RAIDER | 6 | Video game with the character Lara Croft: Tomb __ |
| 53% | MYST | 4 | Video game franchise with the main character Atrus |
| 53% | THESIMS | 7 | Video game franchise with the cheat code "rosebud" |
| 53% | JONSNOW | 7 | Game of Thrones character with the direwolf Ghost |
| 52% | SEGA | 4 | Video game company with the Super Monkey Ball franchise |
| 52% | GUITARHERO | 10 | Video game series with a Warriors of Rock edition |
| 52% | SEGA | 4 | Video game company with the "Virtua Fighter" franchise since 1993 |
| 52% | DIABLO | 6 | Video game series with "Hellfire" and "Lord of Destruction" expansions |
| 51% | UNDERTALE | 9 | 2015 indie video game with the song "Megalovania" |
| 51% | HALO | 4 | 2001 video game with the subtitle "Combat Evolved" |
| 51% | SEGA | 4 | Video game company with the After Burner and Virtua Fighter franchises |
| 51% | CLUE | 4 | Game that begins with the murder of Mr. Boddy |
| 50% | ELDENRING | 9 | 2022 video game by the developers of the Souls series |
| 50% | DONEKONG | 8 | 1981 video game that featured the first appearance of Mario |
| 50% | PSY | 3 | Rapper with the most-viewed YouTube video of all time |
| 50% | UNO | 3 | Popular card game with a lot of colors |
| 50% | MYST | 4 | Popular game with the sequel Riven |
| 50% | NEEDFOR | 7 | "___ Speed," Dominic Cooper movie based on a video game of the same name: 2 wds. |