| 100% | SEGMENT | 7 | Portion, as of a talk show |
| 65% | HOST | 4 | Star of a talk show |
| 65% | BOOKERS | 7 | Part of a talk show staff |
| 62% | ELMO | 4 | Nonhuman host of a talk show on HBO Max |
| 57% | RONREAGAN | 9 | Host of a short-lived talk show |
| 57% | INTERVIEW | 9 | Part of a late-night talk show |
| 56% | ARSENIOHALL | 11 | Talk show host who won a season of "Celebrity Apprentice" |
| 56% | RUPAUL | 6 | Host of a self-titled 1990s talk show |
| 56% | ACTIN | 5 | Be part of, as a show |
| 56% | SEGMENTS | 8 | Portions of talk shows |
| 54% | ALLOT | 5 | Assign portions, as a piece of land to heirs |
| 54% | LIVE | 4 | Shown as it happens, instead of from a recording |
| 53% | ANECDOTES | 9 | A lot of talk show talk |
| 53% | GUESTAPPEARANCE | 15 | Talk show drop-by ... and a literal feature of 17-, 25-, 37- and 49-Across |
| 52% | SAMPLE | 6 | Use a portion of, as one song in another |
| 52% | BAR | 3 | Unit of reception, as shown on a cell phone |
| 51% | CLIP | 4 | Short segment of a movie shown on a talk show |
| 51% | FANDOM | 6 | Group of obsessive followers, as of a TV show |
| 51% | LAPELMIC | 8 | Bit of gear for a talk show host |
| 51% | PANEL | 5 | Discussion group on a talk show |
| 51% | GUEST | 5 | One appearing on a talk show |
| 51% | ELMO | 4 | Muppet who hosted a talk show |
| 51% | DREW | 4 | Actress Barrymore with a talk show |
| 51% | ARSENIOHALL | 11 | Host of a 1990s late-night talk show that was briefly revived 20 years later |
| 50% | ELLENDEGENERES | 14 | Talk show host and star of a 1990s ABC sitcom, whose title was her first name: 2 wds. |
| 50% | TOERRISHUMAN | 12 | Start of a Pope line about fallibility ... as shown by 19-, 25-, 42- and 55-Across? |
| 49% | ROSIEODONNELL | 13 | Host of a self-titled talk show who hosted the 1999 and 2000 Grammy ceremonies: 2 wds. |
| 49% | PHONEIN | 7 | Call a talk show |
| 49% | IDOL | 4 | Laine Hardy's title as a result of winning a 2019 reality show |
| 49% | THEME | 5 | Subject of a talk |