| 100% | ABRAHAMLINCOLN | 14 | President who signed the Yosemite Valley Grant Act in 1864, setting aside land for preservation for the first time: 2 wds. |
| 32% | GEOFFREYRUSH | 12 | "Shine" star who was the first Australian to be nominated for Oscars in two acting categories (2 wds.) |
| 32% | JOSEFELICIANO | 13 | His 1970 song "Feliz Navidad" hit the top 10 for the first time ever in 2020: 2 wds. |
| 31% | CHUCKBERRY | 10 | His 1958 song "Run Rudolph Run" hit the top 10 for the first time ever in 2021: 2 wds. |
| 31% | CORAZONAQUINO | 13 | Former Philippine president who received the Fulbright Prize for International Understanding in 1996: 2 wds. |
| 31% | RAMIMALEK | 9 | Actor who became the first one of Egyptian heritage to win an Oscar for Best Actor in 2019: 2 wds. |
| 31% | NELSONMANDELA | 13 | Former South African president who received the Fulbright Prize for International Understanding in 1993: 2 wds. |
| 31% | DAWNEDON | 8 | Realised it for the first time: 2 wds. |
| 30% | JOSEABREU | 9 | First baseman for the White Sox who won the American League MVP award in 2020: 2 wds. |
| 30% | JAMESBOND | 9 | British spy played by 33-Across for the first time in 48-Across (2 wds.) |
| 30% | WAYNEGRETZKY | 12 | Hockey Hall of Famer who scored 5 goals in a single game four times for the Edmonton Oilers: 2 wds. |
| 30% | MARIOLEMIEUX | 12 | Hockey Hall of Famer who scored 5 goals in a single game four times for the Pittsburgh Penguins: 2 wds. |
| 30% | FDR | 3 | President who signed the Social Security Act, for short |
| 30% | GWENJORGENSEN | 13 | American distance runner and two-time ITU World Champion who was the first to win a triathlon gold for USA in the Olympics: 2 wds. |
| 30% | DEANMARTIN | 10 | His 1959 song "Let It Snow! Let It Snow! Let It Snow!" hit the top 10 for the first time ever in 2021: 2 wds. |
| 30% | JAMESGARFIELD | 13 | 20th President of the United States, who was shot after being in office for only 200 days: 2 wds. |
| 30% | JIMMYCARTER | 11 | 39th US president who published "Why Not the Best?" in 1976, for his presidential campaign: 2 wds. |
| 30% | BECKYHAMMON | 11 | First woman to act as head coach in an NBA game, for the San Antonio Spurs in 2020: 2 wds. |
| 30% | STANLEYTUCCI | 12 | Two time Emmy winner for his films "Winchell" and "Monk", who plays the role of Merlin, in 30a : 2 wds. |
| 29% | MBEKI | 5 | South African president who was instrumental in bringing the FIFA World Cup to Africa for the first time |
| 29% | ROSEANNEBARR | 12 | Former sitcom star who ran for president in 2012 on the Peace and Freedom Party ticket: 2 wds. |
| 29% | WINTERSBONE | 11 | 2010 film set in the Ozarks for which 15-/48-Across received her first Oscar nomination: 2 wds. |
| 29% | WOODROWWILSON | 13 | 28th President of the United States who issued a proclamation declaring the first national Mother's Day in 1914: 2 wds. |
| 29% | BRYANTROTTIER | 13 | Hockey Hall of Famer who scored 5 goals in a single game two times for the New York Islanders: 2 wds. |
| 29% | CAMNEWTON | 9 | Former Panthers quarterback and first overall draft pick in 2011 who signed with the Patriots in 2020: 2 wds. |
| 29% | RICHARDPRYOR | 12 | "Silver Streak" star who was awarded the very first Mark Twain Prize for American Humor in 1998: 2 wds. |
| 29% | CANDACEPARKER | 13 | Two-time WNBA MVP who led the 2021 playoffs in rebounds for the Chicago Sky in their first-ever WNBA championship win (2 wds.) |
| 29% | BARBIE | 6 | Doll that ran for president for the first time in 1992 |
| 29% | WOMENSWORLDCUP | 14 | FIFA event held for the first time in 1991 (3 wds.) |
| 29% | PETERFONDA | 10 | Actor who is the son of legendary actor Henry, famous for playing the villain in "Once Upon a Time in the West": 2 wds. |