| 100% | MARINEONE | 9 | Presidential carrier that flew with an all-women crew for the first time in 2009 |
| 38% | SPACEWALK | 9 | NASA event that consisted of all women for the first time (October, 2019) |
| 36% | SAUDI | 5 | ___ Arabia (nation where women voted for the first time in 2015) |
| 35% | BARBIE | 6 | Doll that ran for president for the first time in 1992 |
| 35% | TETRIS | 6 | Video game “beaten” for the first time, in 2023, by thirteen-year-old Willis Gibson, who advanced so far that the screen froze |
| 34% | TEN | 3 | Thriller/horror film with an all-female cast that premiered at the Boston Underground Film Festival in 2014 |
| 34% | GRAYHOLE | 8 | Outer space phenomenon photographed for the first time in 2019 |
| 34% | SAUDIS | 6 | Women who were legally permitted to drive for the first time in 2018 |
| 34% | WOMENSWORLDCUP | 14 | FIFA event held for the first time in 1991 (3 wds.) |
| 34% | VINYLS | 6 | Records that outsold CDs in 2022, for the first time in 35 years |
| 33% | RADIO | 5 | It was used to play music for the first time in 1906 |
| 32% | SOLOED | 6 | Flew alone for the first time |
| 32% | JAMESBOND | 9 | British spy played by 33-Across for the first time in 48-Across (2 wds.) |
| 32% | VINYL | 5 | Medium that outsold CDs in 2020 for the first time since the 1980s |
| 32% | POI | 3 | Food that tourists in Hawaii often try for the first time |
| 32% | ELSA | 4 | "For the First Time in Forever" duettist |
| 31% | AMYMCGRATH | 10 | First woman to fly an F/A-18 in combat for the U.S. Marine Corps |
| 31% | ACHES | 5 | Some things to complain about after you've just played flag football for the first time in nine years |
| 30% | SOPRANINO | 9 | Term for a musical instrument such as a recorder or saxophone with the highest pitch of all those in its family |
| 30% | SWUM | 4 | Like the English Channel for the first time in 1875 |
| 30% | ELSA | 4 | One of two Disney characters singing "For the First Time in Forever" |
| 30% | AND | 3 | The word that an ampersand stands in for |
| 29% | BAD | 3 | Michael Jackson album with songs like "Man in the Mirror," that went on to become one of the best-selling albums of all time |
| 29% | NEWLY | 5 | For the first time |
| 29% | ASIA | 4 | Where the Olympics were held for the first time in 1964 |
| 29% | USPOSTAGE | 9 | It fell in 2016 for the first time since 1919 |
| 29% | DRWHO | 5 | BBC classic whose title role will be played by a woman for the first time in 2017 |
| 29% | JOE | 3 | "Little ___ the Wrangler," classic western song that's in the Top 100 Western songs of all time fitting for a "National Day of the Cowboy" playlist |
| 29% | SECRETARIAT | 11 | Thoroughbred racehorse who won the Triple Crown on June 9, 1973, and who set fastest time records in all three races that remain unbroken (2 wds.) |
| 29% | BCNR | 4 | For the First Time band, familiarly |