| 100% | NOBEL | 5 | Prize that was first awarded in 1901 |
| 53% | OBERLIN | 7 | Ohio college that was the first in the U.S. to award degrees to women |
| 52% | JANEADDAMS | 10 | First American woman to be awarded the Nobel Peace Prize, in 1931: 2 wds. |
| 52% | TONY | 4 | ___ Awards, Broadway awards that you will see the first edition of in 1947 |
| 49% | PEACEPRIZE | 10 | Award established by Alfred Nobel that was first bestowed on December 10, 1901 (2 wds.) |
| 48% | CORI | 4 | Gerty Theresa ___, biochemist who was the first woman to be awarded the Nobel Prize in Physiology or Medicine |
| 48% | IPAD | 4 | Tablet that was first released in 2010 |
| 48% | RICHARDPRYOR | 12 | "Silver Streak" star who was awarded the very first Mark Twain Prize for American Humor in 1998: 2 wds. |
| 47% | MEDAL | 5 | Olympic gold, silver, or bronze prize that is circular in shape |
| 47% | GUAC | 4 | Dip that was first developed in Mexico, for short |
| 47% | MEDEA | 5 | Tragedy that was first performed in 431 B.C. |
| 45% | INCISORS | 8 | Teeth that are typically the first to grow in |
| 45% | SUN | 3 | Capri ___, German juice concentrate drink that was first introduced to American markets in 1981 |
| 45% | ODESSA | 6 | City that was home to the first car in Russia |
| 44% | PRIME | 5 | ___ Day, annual deal event that was first held on Amazon's 20th anniversary in 2015 |
| 44% | POLECAR | 7 | The vehicle that is first out on the track in Indy racing, say: 2 wds. |
| 44% | THEROBE | 7 | 1953 Biblical epic that was the first film released in CinemaScope |
| 44% | ARK | 3 | Lost object that was raided in the first Indiana Jones movie |
| 44% | ESPYS | 5 | Awards that were hosted by Danica Patrick in 2018 |
| 44% | NECCO | 5 | ___ Wafers (candy that was first produced in 1847) |
| 43% | REDDESERT | 9 | 1964 Antonioni film that was his first to be shot in color |
| 43% | MARIETTA | 8 | Ohio town that was the first permanent settlement in the state (1788) |
| 43% | DYNAMITE | 8 | 2020 BTS hit that was their first song fully recorded in English |
| 43% | MERIT | 5 | Pulitzer Prize is awarded for this in literature |
| 43% | REEL | 4 | Dance that was first referred to in the 1590 witchcraft trial of Doctor Fian in "Edenbrough", Scotland |
| 43% | BALL | 4 | Times Square ___ Drop, New Year event that was first held on New Year's Eve in 1907 |
| 43% | DAMN | 4 | Kendrick Lamar's album that was awarded the 2018 Pulitzer Prize for Music |
| 43% | SHALOMMEIRTOWER | 15 | Tel Aviv skyscraper that was the first to be built in the Mideast |
| 43% | ERNANI | 6 | Verdi work that was the first opera to be recorded in its entirety |
| 43% | PALM | 4 | Co. that was the first to successfully market a PDA worldwide in 1997 |