| 100% | PROTON | 6 | Professor ___, fictional science show host who inspired Leonard and Sheldon in "The Big Bang Theory" |
| 43% | JIMPARSONS | 10 | Actor who portrayed Sheldon Cooper in "The Big Bang Theory," and is the narrator in "Young Sheldon": 2 wds. |
| 41% | RAJ | 3 | "The Big Bang Theory" chum of Sheldon and Leonard |
| 40% | RAJ | 3 | "The Big Bang Theory" pal of Sheldon, Leonard, and Howard |
| 39% | KLINGON | 7 | Fictional language spoken by Sheldon and Leonard on "The Big Bang Theory" |
| 38% | SHELDON | 7 | Who Amy marries in The Big Bang Theory |
| 37% | WIL | 3 | Wheaton who starred in The Big Bang Theory |
| 37% | IRA | 3 | ___ Flatow, engineer and "Newton's Apple" host who cameoed in "The Big Bang Theory" |
| 36% | BAZINGA | 7 | Sheldon word for "gotcha" in The Big Bang Theory |
| 36% | GALECKI | 7 | Johnny __ plays Leonard in The Big Bang Theory |
| 36% | PARSONS | 7 | Jim who plays Sheldon on The Big Bang Theory |
| 36% | BIALIK | 6 | Mayim who played Amy in The Big Bang Theory |
| 36% | CHUCKLORRE | 10 | Creator of "Two and a Half Men" and "The Big Bang Theory," who is also the co-creator of CBS's new show "Young Sheldon": 2 wds. |
| 36% | JIMPARSONS | 10 | "The Big Bang Theory" actor who played Michael in "The Boys in the Band": 2 wds. |
| 35% | CENTER | 6 | The Comic ___ of Pasadena, the store frequented by Sheldon, Raj, Howard, and Leonard in "The Big Bang Theory" |
| 35% | ARMITAGE | 8 | Child actor Iain who plays the title role in "The Big Bang Theory" spin-off "Young Sheldon" |
| 35% | GALECKI | 7 | Johnny —, actor who plays Leonard in US sitcom The Big Bang Theory |
| 35% | GALECKI | 7 | Johnny —, actor who played Leonard in US sitcom The Big Bang Theory |
| 35% | YLEM | 4 | Matter in the Big Bang theory |
| 35% | RAJ | 3 | Pal of Sheldon and Leonard on "The Big Bang Theory" |
| 35% | LORRE | 5 | "The Big Bang Theory" and "Young Sheldon" co-creator Chuck |
| 34% | RAJ | 3 | "The Big Bang Theory" character who was born in New Delhi |
| 34% | NERDY | 5 | Like most characters in The Big Bang Theory |
| 34% | AMY | 3 | Sheldon's girlfriend in "The Big Bang Theory" |
| 33% | BIALIK | 6 | The Big Bang Theory and Blossom star Mayim |
| 33% | MAYIM | 5 | "The Big Bang Theory" actress __ Bialik who is also a scheduled 2021 "Jeopardy!" guest host |
| 33% | GALECKI | 7 | Johnny —, actor who plays Leonard Hofstadter in US television sitcom The Big Bang Theory |
| 33% | IRA | 3 | ___ Flatow, "Newton's Apple" host who cameoed in "The Big Bang Theory" |
| 33% | RAJ | 3 | Pal of Howard, Sheldon, and Leonard on "The Big Bang Theory" |
| 33% | BAZINGA | 7 | Sheldon Cooper's catchphrase in "The Big Bang Theory" |