| 100% | APOLLO | 6 | Project that led to the first moonwalk |
| 52% | XYZAFFAIR | 9 | Scandal that led to the Quasi-War |
| 52% | SUEZ | 4 | Canal that leads to the Red Sea |
| 51% | ELBE | 4 | German river that leads to the North Sea |
| 51% | FRANZ | 5 | Ferdinand whose death led to the First World War |
| 51% | AERIALSHOT | 10 | Type of photo that led to the "Streisand effect" |
| 50% | REDSCARE | 8 | Panic that led to the blacklisting of the Hollywood Ten |
| 50% | SETUP | 5 | Part of a joke that leads to the punch line |
| 50% | ARABSPRING | 10 | Series of uprisings that led to the ouster of Hosni Mubarak |
| 48% | VIADUCT | 7 | Word that led to the "Why a duck?" routine by the Marx brothers |
| 48% | ART | 3 | Cake ___, trend featuring hyperrealistic cakes that led to the "Is it Cake?" meme |
| 48% | DUMBARTON | 9 | __ Oaks, conference that led to founding of the UN |
| 48% | ITINA | 5 | Memoir that led to the movie "What's Love Got to Do With It" |
| 48% | THEELEPHANTMAN | 14 | 1980 film that led to the creation of the Academy Award for Best Makeup |
| 47% | SAY | 3 | "___ the first thing that comes to mind" |
| 47% | NIH | 3 | Org. that led the Human Genome Project |
| 46% | APOLLO | 6 | NASA project that took mankind to the Moon |
| 46% | STATEDEPARTMENT | 15 | Thomas Jefferson was the first to lead it |
| 45% | APOLLO | 6 | NASA space project that took humans to the moon |
| 45% | PLAYOFFS | 8 | Qualifying games that lead up to the Super Bowl |
| 45% | ROSEANNE | 8 | Sitcom that led to "The Conner Family" |
| 45% | BIGDIG | 6 | Construction project that gave rise to the Ted Williams Tunnel |
| 45% | WORDASSOCIATION | 15 | "Answer with the first thing that comes to mind" exercise |
| 44% | THETORTURED | 11 | With 35-Across, 2024 album that led to a new era in the Eras Tour |
| 44% | DANICAPATRICK | 13 | First woman to lead the Indy 500: 2 wds. |
| 43% | YELLOW | 6 | Color of the road that led to the Wizard of Oz |
| 42% | INCISORS | 8 | Teeth that are typically the first to grow in |
| 42% | EKG | 3 | Procedure that involves leads to the chest, for short |
| 41% | SHOWNOUT | 8 | Led to the exit |
| 41% | GALILEO | 7 | Astronomer who was the first to discover that the Milky Way was made up of stars |