| 100% | LES | 3 | Pumpkin colored item that all astronauts ascending to and re-entering from the ISS wore from 1994 to 1998 (abbr.) |
| 26% | BOOK | 4 | Item you might check out from the library and be "glued" to |
| 25% | ITAL | 4 | From the nation that gave us pizza and Parmesan: Abbr. |
| 25% | RGTR | 4 | MMORPG running from 2007 to 2009 that took place on planets Arieki and Foreas between humanity and the Bane (abbr.) |
| 25% | TUTU | 4 | The dress that Sonya from "Madagascar" wears all the time |
| 25% | SPACESUIT | 9 | Item that originally caused the postponement of the recent ISS all-female EVA |
| 25% | CCLAMP | 6 | Item that the stage crew probably uses to hang the lighting and speakers |
| 25% | NERVE | 5 | Bundle of fibers that transmits impulses to and from the brain |
| 24% | NORMMACDONALD | 13 | Deadpan comic and voice actor who was the "Weekend Update" anchor from 1994 to 1997: 2 wds. |
| 24% | USAIR | 5 | Carrier that operated the hourly shuttle from Logan to LaGuardia and Ronald Reagan up until October 2015 |
| 24% | NASA | 4 | Agency that's sent astronauts to the moon: Abbr. |
| 24% | WYE | 3 | Maryland river that lent its name to the memorandum negotiated between Israel and the Palestinian Authority in 1998 |
| 24% | ISEW | 4 | Indicator intended to replace the GDP that considers items such as income distribution and costs of pollution (abbr.) |
| 24% | JENNIFER | 8 | Name that may have been derived from the juniper plant and common to 13a, 18a, 32a, and 39d |
| 24% | ESTE | 4 | Noble family of Italy that governed Modena and Reggio from the 13th- to the 18th-century |
| 24% | HAIL | 4 | Pellets of ice from the sky that could cause damage to buildings and cars |
| 24% | HOP | 3 | Word that can follow "bunny" and "Lindy" to make dances from the mid-1900s |
| 24% | ERA | 3 | 2021 addition to the Russian segment of the ISS that will include two limbs, two grippers, two wrists and an elbow joint (abbr.) |
| 24% | CATCHAWAVE | 10 | 1963 single by 29-Across from 39-Across that has the lyrics "You paddle out turn around and raise / And baby that's all there is to the coastline craze" (3 wds.) |
| 24% | ATL | 3 | City that's home to the Hawks and Falcons: Abbr. |
| 23% | BREEN | 5 | Extraterrestrial species from the "Star Trek" franchise that Thot Gor and Thot Pran belonged to |
| 23% | MAN | 3 | "He-___ and the Masters of the Universe," animated series that ran from 1983 to 1985 |
| 23% | ILL | 3 | State that's home to the Bears and the Bulls: Abbr. |
| 23% | ILL | 3 | State that's home to the Bulls and the Blackhawks: Abbr. |
| 23% | SSE | 3 | Direction that's down and a little to the right: Abbr. |
| 23% | YUMA | 4 | Arizona city that produces about 90 percent of all leafy vegetables grown in the United States from November to April |
| 23% | BOOK | 4 | Item commonly borrowed from the library ... or a word that goes with 25a, 36a, 42a, 7d, and 37d |
| 23% | ESTE | 4 | Noble family of Italy that governed Modena and Reggio from the 13th to the 18th century |
| 23% | TRANSYLVANIA | 12 | Region of central and NW Romania that belonged to Hungary from the 11th century until 1918 |
| 23% | TRANSYLVANIA | 12 | Region of central and northwest Romania that belonged to Hungary from the 11th century until 1918 |