| 100% | ISITI | 5 | Question asked in Matthew 26:22 |
| 63% | ISITI | 5 | Question asked 12 times in Matthew |
| 58% | WHOAM | 5 | Question asked in a "Les Misérables" song |
| 57% | ISITI | 5 | Question to the Lord in Matthew 26 |
| 54% | HOW | 3 | Question asked in befuddlement |
| 52% | WHEREAMI | 8 | Question asked in a foggy state |
| 52% | ISITLIVE | 8 | Question asked in classic 1970s ads |
| 52% | ISITI | 5 | Query in Matthew 26 |
| 51% | THISOLDTHING | 12 | Question asked modestly in response to "That looks great on you" |
| 51% | ISITI | 5 | Famous query in Matthew 26 |
| 51% | ISITI | 5 | Matthew 26 question |
| 49% | YESNO | 5 | Like questions asked in Twenty Questions: Hyph. |
| 49% | YESNO | 5 | Like the questions asked in 20 Questions |
| 49% | YESNO | 5 | Like the questions asked in Guess Who? |
| 48% | AMILATE | 7 | Question asked while running in the door |
| 48% | WHATAMIGONNADO | 14 | Question asked by someone in a dilemma |
| 47% | ISITI | 5 | Question in Matthew |
| 46% | AMILATE | 7 | Question asked upon arriving at an in-progress meeting |
| 44% | PUTONX | 6 | Asked a hard question in public, say |
| 44% | WHATSSOFUNNY | 12 | Question asked in response to the starts of both words in 20-, 28- and 48-Across |
| 43% | CANYOUHEARMENOW | 15 | Question asked with a raised voice, as demonstrated in three long puzzle answers |
| 42% | ITI | 3 | Lord, is ___?: Matthew 26:22 |
| 40% | SEALIONING | 10 | Asking seemingly innocent questions in order to waste someone's time |
| 40% | STS | 3 | 22 of the 26 letters of the alphabet, in D.C. |
| 40% | ITI | 3 | "Lord, is ___?": Matthew 26:22 |
| 39% | DEAL | 4 | Question or answer in "___?" ... "___!" |
| 38% | MAYI | 4 | "___ ask a question?": 2 wds. |
| 38% | WHY | 3 | Question I often ask myself when working on puzzles at three in the morning |
| 38% | TENNISANYONE | 12 | Question you might feel like asking after seeing nine key words in this puzzle? |
| 38% | ASIT | 4 | "...___ is in heaven": Matthew |