| 100% | BABBITT | 7 | Raymond, played by Dustin Hoffman in Rain Man |
| 60% | RAYMOND | 7 | Autistic savant played by Dustin Hoffman in 15-Across |
| 48% | MUMBLES | 7 | Dick Tracy villain played by Dustin Hoffman |
| 48% | BERNSTEIN | 9 | Carl __, reporter played by Dustin Hoffman on film |
| 47% | LITT | 4 | Played by Rick Hoffman in Suits, Lewis |
| 44% | LENNYBRUCE | 10 | Real-life comic played in film by Dustin Hoffman |
| 44% | RAINMAN | 7 | Dustin Hoffman plays a savant in this drama |
| 43% | BLACKJACK | 9 | Card game played by Tom Cruise and Dustin Hoffman in "Rainman" |
| 42% | EDNA | 4 | "Hairspray" role traditionally played by a man in drag |
| 40% | PREJEAN | 7 | Real-life death penalty opponent played by Sarandon in "Dead Man Walking" |
| 40% | JAMESBRADDOCK | 13 | Boxer played by Russell Crowe in "Cinderella Man" (2 wds.) |
| 39% | JONATHAN | 8 | Role played by Boris Karloff on Broadway and Raymond Massey in the film |
| 38% | PORTHOS | 7 | Classic role played by Gérard Depardieu in "The Man in the Iron Mask" |
| 38% | BIGFOOT | 7 | Creature played by both Andre the Giant and Ted Cassidy in "The Six Million Dollar Man" |
| 37% | HARRYLIME | 9 | Character played by Orson Welles in 1949 film thriller The Third Man |
| 37% | LENNY | 5 | Comedian played by Dustin |
| 37% | MAN | 3 | "Rain ___," 1988 American comedy drama film starring Dustin Hoffman and Tom Cruise in which Hoffman plays an autistic savant |
| 36% | DEDE | 4 | ___ Tate, character played by Jodie Foster who was mom to Fred in the 1991 film "Little Man Tate" |
| 36% | TONY | 4 | ___ Stark, character played by Robert Downey Jr. in the "Iron Man" film series who sports a distinctive iconic goatee |
| 36% | GRADUATE | 8 | Dustin Hoffman, in a 1967 movie |
| 35% | KILLERJOE | 9 | Title hit man played by Matthew McConaughey in a 2011 film |
| 35% | AUTISM | 6 | Raymond's condition in "Rain Man" |
| 35% | HOOK | 4 | 1991 film in which Dustin Hoffman plays a pirate captain |
| 35% | DUSTINHOFFMAN | 13 | "Rain Man" actor who played Captain Hook in "Hook": 2 wds. |
| 35% | MAY | 3 | Aunt played by Marisa Tomei in "Spider-Man: Homecoming" |
| 35% | STORM | 5 | Superhero played by Alexandra Shipp in "X-Men: Apocalypse" |
| 34% | CHEF | 4 | 2014 film in which Dustin Hoffman plays an uncreative restaurant owner |
| 34% | TOOTSIE | 7 | 1982 film in which Dustin Hoffman plays a cross-dressing actor |
| 34% | LENNY | 5 | 1974 biopic starring Dustin Hoffman in the title role |
| 34% | MAN | 3 | Dustin Hoffman and Tom Cruise movie Rain __ |