| 100% | CATSAPPLAUSE | 12 | Reaction to opening a can of Whiskas? |
| 54% | ITSACIRCUS | 10 | Reaction to a frenzied scene, and what could be said of the beginnings of the starred answers |
| 54% | ANGLER | 6 | One opening a can of worms? |
| 53% | RINGPULL | 8 | Finger tool to open a can |
| 53% | ANGLER | 6 | One who opens a can of worms? |
| 49% | WHUP | 4 | A can of this might be opened in an argument |
| 49% | DOUBLETAKE | 10 | Surprised reaction ... or a hint to what can precede both halves of the answers to the starred clues |
| 49% | WINCE | 5 | Reaction to a shot of Malört, maybe |
| 48% | OOH | 3 | Reaction to a juicy piece of gossip, maybe |
| 46% | BAITSHOP | 8 | Where you might open a whole can of worms? |
| 45% | AIROUT | 6 | Open a window to get rid of the odors inside: 2 wds. |
| 45% | WINDOW | 6 | Opening in a wall to see out of |
| 45% | OOF | 3 | Reaction of a cad to a 101-Across |
| 45% | ONLYINAMERICA | 13 | His reaction to the election of a Jewish mayor in Dublin |
| 44% | SORRYIASKED | 11 | "Didn't mean to open that can of worms" |
| 44% | RBIS | 4 | A tater can produce up to four of these |
| 44% | ANGLER | 6 | One opening up a can of worms? |
| 44% | DEARSIR | 7 | Opening line of a letter to a gentleman: 2 wds. |
| 44% | UPHILL | 6 | A challenge can be likened to this kind of battle |
| 44% | ALLERGY | 7 | Abnormal reaction of the body to a substance |
| 43% | REFLEX | 6 | Involuntary reaction of a body part to a stimulus |
| 43% | SKELETONKEY | 11 | It can open a lot of doors for you |
| 43% | KEYCARD | 7 | Plastic to open the door of a hotel room |
| 43% | INERT | 5 | Hard to get a reaction out of |
| 42% | GATE | 4 | Entryway to a house that can be opened and closed |
| 42% | ANTMAN | 6 | Superhero who can shrink to the size of a bug |
| 42% | CORKSCREW | 9 | Handy if you have to open a bottle of wine |
| 42% | SHUTTER | 7 | Doors of a camera lens that open to control light |
| 42% | PIT | 3 | Part of a date that could lead to more dates |
| 42% | AINT | 4 | "I ___ reading all that" (meme posted in reaction to a long series of Twitter posts) |