| 100% | YECCH | 5 | Reaction to the starts of the five longest puzzle answers |
| 66% | GENEEDITING | 11 | Molecular manipulation technique ... and a hint to the starts of the three other longest puzzle answers |
| 65% | HEEEEERESJOHNNY | 15 | Classic TV intro which can be applied to the starts of the four other longest puzzle answers |
| 65% | AGES | 4 | A very long time ... or a hint to the starts of the answers to the five starred clues |
| 65% | INA | 3 | With 60-Down, on one's game ... and hint to the start of this puzzle's longest answers |
| 63% | TOE | 3 | Digit associated with the starts of this puzzle's five longest answers |
| 62% | SEEALSO | 7 | Cross-reference indicator ... and directions to the link among the five longest puzzle answers |
| 62% | WIRED | 5 | Tense with excitement ... and a hint to the ends of the four longest puzzle answers |
| 61% | NEWYEARSEVE | 11 | Time to sing the tune suggested by the starts of 10 long answers in this puzzle |
| 61% | MIXEDGREENS | 11 | Simple salad ... and what the starts of the five other longest answers are? |
| 61% | TAKEITDOWNANOTCH | 16 | Reduce one’s excitement slightly ... or what you have to do to the final letter of five long answers in this puzzle? |
| 60% | IBELIEVEICANFLY | 15 | R. Kelly hit whose last title word is aptly rhymed with "sky" in the lyrics ... and a hint to the starts of the other four longest puzzle answers |
| 59% | ILLSECONDTHAT | 13 | "Amen!" ... or a hint to the start of four other long answers |
| 58% | OLD | 3 | Unlike the starts of this puzzle's four longest answers |
| 57% | FALLINGLEAVES | 13 | Autumn occurrence, and a hint to the start of the other four longest Down answers |
| 57% | ANIMALHOUSE | 11 | Raucous frat film, and a hint to the starts of the other four long Across answers |
| 56% | ALLTHATJAZZ | 11 | Bob Fosse film title relevant to the starts of eight answers in this puzzle |
| 56% | BUTTERFLY | 9 | Word that can precede the starts of the answers to the five starred clues |
| 56% | OCEAN | 5 | Body that appears at the start of the answers to the five starred clues |
| 55% | JUGBAND | 7 | *Where the starts of the answers to the five starred clues can all be found |
| 54% | OPPOSITESATTRACT | 16 | Saying about compatible partners … as suggested by the starts of the answers to this puzzle's starred clues? |
| 53% | INSIDEOUT | 9 | Reversed, in a way ... and a hint to the creation of five puzzle answers |
| 53% | PISAITALY | 9 | Home to this puzzle's featured structure, as hinted at by the starts of the answers to the starred clues |
| 52% | ABRAHAMLINCOLN | 14 | Statesman born 2/12/1809 whose surname can precede the starts of four long puzzle answers |
| 52% | PINACOLADA | 10 | What I'm going to have after I've finished writing these clues and it's spelled out with the first two letters of five of the longest puzzle answers |
| 52% | SPA | 3 | Resort hidden in the five longest puzzle answers |
| 52% | MISSINGINGREDIENT | 17 | Feature of this puzzle (hint: string together the letters omitted from the starts of 10 long answers) |
| 52% | SMOKEYBEAR | 10 | Character who's wary of the starts to this puzzle's theme answers |
| 51% | ANYMOMENT | 9 | "It's about to happen" ... or what each of the four other longest answers in this puzzle has? |
| 51% | RISINGSEALEVELS | 15 | One effect of global warming, and a hint to the five longest Down answers |