| 100% | SELKIRK | 7 | Real-life sailor on whom Crusoe was based |
| 54% | ANNA | 4 | ___ Wintour, real-life editor on whom "The Devil Wears Prada" is based |
| 51% | PATCH | 5 | ___ Adams, character based on a real-life doctor who was played by Robin Williams in the eponymous 1998 film |
| 49% | RANGE | 5 | "At Close ___," crime drama film featuring Sean Penn as Bradford Whitewood Jr. which is based on a real life crime family |
| 49% | AHAB | 4 | Literary character on whom Captain Hook is based |
| 48% | ALCOTTS | 7 | Sisters on whom "Little Women" was loosely based |
| 47% | GOODFELLAS | 10 | Martin Scorsese's crime film based on the life of Henry Hill who was associated with the Lucchese crime family |
| 46% | NORA | 4 | ___ Barnacle, on whom Molly Bloom of "Ulysses" was based |
| 46% | ATTILA | 6 | Historical figure on whom a Verdi opera is based |
| 46% | EMMA | 4 | Literary character on whom Cher from Clueless is based |
| 45% | LYNN | 4 | Country singer on whom "Coal Miner's Daughter" is based |
| 45% | TROTSKY | 7 | Political figure on whom Snowball is based in "Animal Farm" |
| 45% | PANDORICA | 9 | The ___, restaurant in NY that is based on "Doctor Who" |
| 44% | YOUNG | 5 | "___ Rock," sitcom starring Dwayne Johnson that is based on his life |
| 43% | ROSS | 4 | Bob on whom Owen Wilson's character is based in 2023's "Paint" |
| 43% | NENE | 4 | Leakes who was on "The Real Housewives of Atlanta" |
| 42% | SEINFELD | 8 | Sitcom co-created by and starring comedian Jerry that is based on his life |
| 42% | BUPKIS | 6 | TV series created by and starring Pete Davidson that is based on his life |
| 42% | BADCALLS | 8 | People being off base about who was on base, perhaps? |
| 42% | RHAPSODY | 8 | "Bohemian ___," 2018 film starring Rami Malek which is based on the life of Freddie Mercury |
| 42% | RAY | 3 | 2004 musical starring Jamie Foxx that is based on the life of soul musician Charles |
| 42% | FUNNY | 5 | "___ Girl," 1968 musical starring Barbra Streisand that is based on the life of Fanny Brice |
| 42% | DAVE | 4 | TV show co-created by and starring Lil Dicky that is based on his life |
| 41% | GLORY | 5 | "Bound for ___," 1976 musical starring David Carradine that is based on the life of Woody Guthrie |
| 40% | LEFT | 4 | "My ___ Foot," biographical drama starring Daniel Day-Lewis which is based on the life of Christy Brown |
| 40% | JEANNIEMAI | 10 | "The Real" cohost who is the sideline correspondent on 17-Across: 2 wds. |
| 39% | OWNINGMAHOWNY | 13 | Philip Seymour Hoffman's movie which is based on a Canadian banker who embezzled money for gambling: 2 wds. |
| 39% | RORSCHACH | 9 | Hermann —, Swiss psychiatrist after whom a personality test based on ink blot interpretation is named |
| 39% | ESTRADA | 7 | "CHiPs" star Erik who was featured on the reality show "The Surreal Life" in 2004 |
| 39% | DIANEKEATON | 11 | Comedic actress who was given an AFI Life Achievement Award on June 8: 2 wds. |