| 100% | MADABOUTYOU | 11 | Recently rebooted 1990s sitcom starring Helen Hunt and Paul Reiser: 3 wds. |
| 45% | MADABOUTYOU | 11 | Series starring Paul Reiser and Helen Hunt, which got a 2019 reboot |
| 41% | WORLDONFIRE | 11 | 2019 World War II BBC drama starring Helen Hunt and Sean Bean: 3 wds. |
| 35% | WHATWOMENWANT | 13 | Romcom starring Mel Gibson and Helen Hunt which grossed $374 million worldwide in 2000: 3 wds. |
| 35% | ASGOODASITGETS | 14 | 1997 romantic comedy starring Helen Hunt and Jack Nicholson: 5 wds. |
| 31% | TWISTER | 7 | 1996 action film starring Helen Hunt and Bill Paxton |
| 31% | THENANNY | 8 | 1990s sitcom starring Fran Drescher: 2 wds. |
| 31% | SISTERSISTER | 12 | 1990s sitcom starring Tia and Tamera Mowry |
| 30% | JUSTSHOOTME | 11 | Sitcom starring David Spade that debuted in 1997 and ran for seven seasons (3 wds.) |
| 29% | THEUNICORN | 10 | CBS sitcom starring 18-Across and 33-Across about a recently widowed father who re-enters the dating scene (2 wds.) |
| 29% | SANFORDANDSON | 13 | Sitcom starring Redd Foxx and Demond Wilson that premiered on January 14, 1972 (3 wds.) |
| 29% | THEGOODPLACE | 12 | 2016-2020 NBC afterlife sitcom starring Kristen Bell and Ted Danson: 3 wds. |
| 28% | THEREALONEALS | 13 | Current ABC sitcom starring Martha Plimpton: 3 wds. |
| 28% | SISTERSISTER | 12 | '90s sitcom starring Tia and Tamera Mowry: 2 wds. |
| 28% | SHAKEITUP | 9 | Chicago-based 2010-2013 sitcom starring Zendaya: 3 wds. |
| 28% | MAD | 3 | "___ About You" (Paul Reiser/Helen Hunt sitcom) |
| 28% | ROSEANNEBARR | 12 | 1990s sitcom star who was the subject of a Comedy Central Roast in 2012: 2 wds. |
| 28% | THEBRADYBUNCH | 13 | Family sitcom starring Robert Reed and Florence Henderson that debuted in 1969 (3 wds.) |
| 27% | THREESCOMPANY | 13 | Classic sitcom starring John Ritter, Joyce DeWitt, and 44-Across (2 wds.) |
| 27% | UPALLNIGHT | 10 | NBC sitcom starring 15-/50-Across as a new mom: 3 wds. |
| 27% | ABOUTABOY | 9 | Current NBC sitcom starring Minnie Driver as a single mom: 3 wds. |
| 27% | TWOUPTWODOWN | 12 | 1979 BBC TV sitcom starring Paul Nicholas and Su Pollard |
| 27% | THEODDCOUPLE | 12 | 2015 American sitcom starring Matthew Perry and Thomas Lennon which is about two friends who learn to overcome their differences: 3 wds. |
| 27% | MADABOUTYOU | 11 | Paul Reiser/Helen Hunt series |
| 27% | SUDDENLYSUSAN | 13 | Sitcom starring 15-Across and 32-Across that premiered in 1996 (2 wds.) |
| 27% | SUPERFUNNIGHT | 13 | ABC sitcom created by and starring 18-Across: 3 wds. |
| 26% | THEODDCOUPLE | 12 | 1970s Neil Simon sitcom starring 17-Across and 41-Across that debuted 50 years ago (3 wds.) |
| 26% | NIGHTCOURT | 10 | 1984-1992 sitcom starring 18-Across, 33-Across, and John Larroquette (2 wds.) |
| 26% | MANWITHAPLAN | 12 | 25-Across sitcom starring 17-Across, 36-Across, and Liza Snyder (4 wds.) |
| 26% | YESMINISTER | 11 | BBC TV sitcom starring Paul Eddington and Nigel Hawthorne that ran from 1980-84 |