| 100% | TEC | 3 | Religious org. of Rev. Cameron Partridge, first openly transgender priest to preach at Washington's Natl. Cathedral (2014) |
| 24% | HELENNASH | 9 | First Black woman to work at Washington University School of Medicine |
| 21% | KIMPETRAS | 9 | First openly transgender woman to have a No. 1 song on the Billboard Hot 100 chart |
| 19% | KNOX | 4 | Washington's first secretary of war |
| 19% | POPELEO | 7 | First religious leader of his title to be called "The Great" |
| 19% | SMALL | 5 | Taylor ___, Vermont's first openly transgender legislator |
| 19% | LIA | 3 | ___ Thomas, first openly transgender athlete to win an NCAA Division I national championship (swimming) |
| 19% | STU | 3 | Rasmussen who was the first openly transgender mayor in the U.S. |
| 18% | INITIALLY | 9 | At the start ... or how the first two letters of each starred clue relate to the answer? |
| 18% | NADIA | 5 | ___ Comaneci, the first gymnast to be awarded a perfect score of 10 at the Olympics |
| 18% | PRELUDE | 7 | __ To War, first of Capra's propaganda films |
| 18% | SIGEP | 5 | First national fraternity to officially welcome transgender members (2014), informally |
| 18% | ACLU | 4 | First national org. to call for Richard Nixon's impeachment |
| 18% | APPLE | 5 | First U.S. company to be valued at $1 trillion |
| 18% | EONS | 4 | The first 2 hours of Pirates: At World's End seemed to go on for ___ until the action came |
| 17% | ISIS | 4 | Actress and activist King who was the first openly transgender competitor on “America’s Next Top Model” |
| 17% | TREE | 4 | "On the first day of Christmas, my true love sent to me, a partridge in a pear ___..." |
| 17% | ALEC | 4 | ___ Greven, "How To Talk to Girls" author who published his first book at the age of 9 |
| 17% | IDINA | 5 | Real first name of the singer introduced by John Travolta at the 2014 Oscars as "Adele Dazeem" |
| 17% | MARTHA | 6 | First name of George Washington's wife |
| 17% | APPLE | 5 | First public U.S. company to be valued at $1 trillion |
| 17% | LAYSHIA | 7 | ___ Clarendon, first openly transgender W.N.B.A. player |
| 17% | BAEZ | 4 | One of the first to record Dylan's songs |
| 17% | TEDDY | 5 | He's to the left of Abe, at Rushmore |
| 17% | MARTHA | 6 | First name of George Washington's First Lady |
| 17% | CHANGESONESTUNE | 15 | Starts looking at things differently, as demonstrated by the first words of the answers to the starred clues? |
| 17% | SSA | 3 | Org. of concern to AARP |
| 17% | VICTORIASSECRET | 15 | Retailer that hired its first openly transgender model in 2019 |
| 17% | NOONE | 5 | Who's on first, at the top of the inning |
| 17% | SOS | 3 | Rihanna's first #1 single (out of 14 to date) |