| 100% | BRANSON | 7 | Richard who flew to the edge of space in 2021 |
| 45% | GLENN | 5 | Astronaut John who is the oldest person to have flown in space |
| 43% | BEZOS | 5 | Amazon founder who flew to space in July |
| 41% | STERIC | 6 | Relating to the arrangement of atoms in space |
| 39% | JULY | 4 | Month in 2021 when Jeff Bezos flew to space and back |
| 39% | UFOS | 4 | In 2021, the U.S. Department of Defense established a group to examine them (abbr.) |
| 38% | ABUT | 4 | Go to the edge of |
| 38% | ALEKSEI | 7 | Leonov who was the first man to walk in space |
| 37% | JET | 3 | The Lippisch Ente was the first one of these to fly, in 1928 |
| 37% | PATTI | 5 | LuPone who plays Joanne in the 2021 Broadway revival of “Company” |
| 37% | APRIL | 5 | Month in 2021 when NASA's Ingenuity became the first powered aircraft to fly on Mars |
| 36% | MOMOA | 5 | Actor Jason who will play Duncan Idaho in the 2021 remake of "Dune" |
| 36% | ICARUS | 6 | In myth, one who flew too close to the sun |
| 36% | OMAR | 4 | Vizquel who's the only shortstop to play in four decades of MLB games |
| 36% | BOSH | 4 | Chris elected to the Basketball Hall of Fame in 2021 |
| 36% | LEASEYDOUX | 10 | "No Time to Die" actress who plays Caprice in "Crimes of the Future" (2 wds.) |
| 35% | RIGGS | 5 | Bobby who lost to Billie Jean King in tennis' "Battle of the Sexes" |
| 35% | BORIS | 5 | Spassky who lost to Bobby Fischer in chess’s Match of the Century |
| 35% | ANGLE | 5 | The edge of a geometrical shape, measured in degrees |
| 35% | BILLRUSSELL | 11 | 2021 Basketball Hall of Fame inductee who was the first Black head coach in the NBA (2 wds.) |
| 35% | WHITSON | 7 | Peggy ___, American astronaut who became the first woman to command the International Space Station in 2007 |
| 35% | EILEEN | 6 | ___ Collins, American astronaut who became the first woman to command a space shuttle mission in 1999 |
| 35% | OLGA | 4 | Merediz who reprised her Tony-nominated role in the 2021 film adaptation of "In the Heights" |
| 35% | ASHLEIGHBARTY | 13 | Australian tennis player who won WTA Player of the Year in 2019 and 2021: 2 wds. |
| 35% | EGON | 4 | Spengler of the Ghostbusters series who once tried to drill a hole in his own head |
| 35% | JACOBY | 6 | Ellsbury who was the first Native American of Navajo descent to play in Major League Baseball |
| 35% | RIGGS | 5 | Bobby who lost to Billie Jean in the Battle of the Sexes tennis match |
| 35% | PELIAS | 6 | King of Iolcos in Greek mythology who sent Jason to fetch the Golden Fleece |
| 35% | ADLER | 5 | Irene who's central to the scandal of "A Scandal in Bohemia" |
| 35% | RICKADELMAN | 11 | 2021 Basketball Hall of Fame inductee who coached five NBA teams in four decades (1989 to 2014) (2 wds.) |