| 100% | LABRATS | 7 | Rodents used in experiments: 2 wds. |
| 69% | LABRAT | 6 | Rodent used for scientific experiments: 2 wds. |
| 63% | LAB | 3 | With 39-Across, rodent used in experiments |
| 56% | TRIPLESEC | 9 | Liqueur used in a cosmopolitan: 2 wds. |
| 56% | ORSO | 4 | Phrase used in an approximation: 2 wds. |
| 56% | MASONJAR | 8 | Glass container used in canning: 2 wds. |
| 56% | IDO | 3 | Phrase used in most marriage vows: 2 wds. |
| 56% | KEYLIME | 7 | Citrus fruit used in pie filling: 2 wds. |
| 56% | FIREEXIT | 8 | Theater door used in an emergency: 2 wds. |
| 56% | WARPDRIVE | 9 | Acceleration technology used in "Star Trek": 2 wds. |
| 55% | OVENMITT | 8 | Heat-resistant glove used in the kitchen: 2 wds. |
| 55% | PLOTTWIST | 9 | Surprise device used in many spy novels: 2 wds. |
| 55% | SNAPPEAS | 8 | Crunchy pod veggies used in stir-fry: 2 wds. |
| 55% | OFNO | 4 | "The umbrella was ___ use in the storm...": 2 wds. |
| 54% | BODYWASH | 8 | Shower gel used in place of bar soap: 2 wds. |
| 54% | RATS | 4 | Rodents sometimes used in lab experiments |
| 53% | FAKEFUR | 7 | Faux fabric used in stuffed toys and fashion accessories: 2 wds. |
| 53% | ICEBUCKET | 9 | Container used in a viral Internet "challenge" of 2014: 2 wds. |
| 53% | IBAR | 4 | A letter-shaped beam used in construction: 2 wds |
| 53% | REDONION | 8 | Purplish vegetable that's sometimes used in guacamole and salsa: 2 wds. |
| 52% | FIREEXITS | 9 | Doors that activate alarms when used in emergencies: 2 wds. |
| 50% | PAINTGUN | 8 | Weapon used in a fun outdoor activity involving colour pellets and commando gear: 2 wds |
| 50% | RAT | 3 | Rodent used in demining |
| 50% | FRUITFLY | 8 | Insect used in genetic research (2 wds.) |
| 49% | LABRAT | 6 | Rodent used in scientific research |
| 49% | RAT | 3 | Rodent used in scientific studies |
| 49% | BEANSPROUTS | 11 | Shoots often used in 46-Across (2 wds.) |
| 49% | KEYLIME | 7 | Citrus fruit used in pie filling (2 wds.) |
| 49% | TIREIRON | 8 | Tool used in changing a flat (2 wds.) |
| 49% | GUINEAPIG | 9 | Person used in experiments |