| 100% | MILE | 4 | Roger Bannister was the first to run it in under four minutes |
| 49% | BANNISTER | 9 | First to run a mile in under 4 minutes: Roger __ |
| 48% | RYUN | 4 | Jim ___, athlete who was the first high school junior to run a mile in under four minutes |
| 41% | FOURMINUTEMILER | 15 | Roger Bannister was the first |
| 41% | ERNANI | 6 | Verdi work that was the first opera to be recorded in its entirety |
| 41% | PGA | 3 | Babe Zaharias was the first woman to compete on its tour, in brief |
| 38% | JIMHINES | 8 | First to run 100m in under 10 seconds, died 2023 |
| 38% | BLAZEATRAIL | 11 | Be the first to accomplish something (and do it spectacularly!) |
| 37% | MBA | 3 | Harvard was the first to offer it (1908) |
| 36% | TOBEY | 5 | Actor Maguire who was the first to play Spider-Man in movies |
| 36% | STATEDEPARTMENT | 15 | Thomas Jefferson was the first to lead it |
| 36% | SECRETBALLOT | 12 | Australia was the first country to implement it |
| 36% | INC | 3 | Business magazine that, in 1981, was the first to feature Steve Jobs on its cover |
| 36% | SHALOMMEIRTOWER | 15 | Tel Aviv skyscraper that was the first to be built in the Mideast |
| 36% | PALM | 4 | Co. that was the first to successfully market a PDA worldwide in 1997 |
| 35% | TOBACCO | 7 | Rolfe was the first to cultivate this in Virginia |
| 35% | TMZ | 3 | Hollywood website that was the first to report Michael Jackson's death in 2009 |
| 35% | ALEKSEI | 7 | Leonov who was the first man to walk in space |
| 35% | MDA | 3 | Org. whose telethon was the first to be viewed globally via the internet in 1998 |
| 35% | ETNA | 4 | The monster Typhon was said to be trapped under it, in Greek myth |
| 35% | ERIECANAL | 9 | The Seneca Chief was the first to travel its full length |
| 35% | CLARINET | 8 | Mozart was the first major composer to write specifically for it |
| 35% | SNL | 3 | Buck Henry was the first to host it five times, briefly |
| 35% | TELEPHONE | 9 | Alexander Graham Bell was the first to patent it |
| 34% | UPFOR | 5 | In the running to be |
| 34% | OTT | 3 | Mel who was the first NL player to surpass 500 home runs |
| 34% | BARRY | 5 | ___ Nelson, American actor who was the first to portray James Bond in a television series titled "Climax!" |
| 34% | LISALESLIE | 10 | L.A. Sparks player who was the first to dunk in a W.N.B.A. game |
| 34% | HAYES | 5 | First president to have a phone in the White House—its number was "1" (1877) |
| 34% | ROSA | 4 | Parks who was the first woman to lie in honor in the Capitol |