| 100% | AMYFISHER | 9 | Role played by Drew Barrymore in a 1993 TV movie based on real life |
| 36% | GLORIASTEINEM | 13 | Feminist journalist played by 15-Across and Alicia Vikander in a 2020 biopic based on the memoir "My Life on the Road" (2 wds.) |
| 35% | CHARLIEWILSON | 13 | Real-life congressman played by Tom Hanks in a 2007 movie: 2 wds. |
| 35% | FORRESTGUMP | 11 | Title role played by Tom Hanks in a 1994 Oscar-winning movie: 2 wds. |
| 34% | FORREST | 7 | "___ Gump," Tom Hanks movie based on a novel by Winston Groom which released in 1994 |
| 34% | GIA | 3 | American supermodel played by Angelina Jolie in a TV movie, ___ Carangi |
| 33% | FREDROGERS | 10 | Real-life children's entertainer played by Tom Hanks in a 2019 movie: 2 wds. |
| 32% | WALTDISNEY | 10 | Real-life Oscar-winning animator played by Tom Hanks in a 2013 movie: 2 wds. |
| 31% | BABARACUS | 9 | Role played by Mr. T on "The A-Team" |
| 31% | BEFORE | 6 | "The Nightmare ___ Christmas," 1993 animated movie based on a poem by Tim Burton |
| 31% | ULEE | 4 | ___ Jackson (role played by Peter Fonda in a 1997 movie) |
| 31% | NEO | 3 | Role played by Keanu Reeves in three movies |
| 31% | NEO | 3 | Role played by Keanu Reeves in four movies |
| 31% | GOD | 3 | Role played by George Burns in three movies |
| 31% | MUCHADOABOUT | 12 | "___ Nothing," a 1993 film based on a Shakespeare play, in which Keanu Reeves starred with the likes of Denzel Washington: 3 wds. |
| 31% | GIA | 3 | Angelina Jolie movie based on a supermodel's life |
| 30% | PATCH | 5 | ___ Adams, character based on a real-life doctor who was played by Robin Williams in the eponymous 1998 film |
| 30% | ADO | 3 | "Much ___ About Nothing" (2013 movie based on a Shakespeare play) |
| 30% | AMELIA | 6 | Title role played by Hilary Swank in a 2009 biopic |
| 30% | ANNIE | 5 | Musical role played by Quvenzhané Wallis in a 2014 remake |
| 30% | POPEYETHESAILOR | 15 | Nautical role played by Robin Williams in a 1980 film |
| 30% | LILO | 4 | Title role played by Maia Kealoha in a 2025 remake |
| 30% | SUGARPLUMFAIRY | 14 | Role played by 16-Across in a 1954 production of "The Nutcracker": 3 wds. |
| 30% | JONATHAN | 8 | Role played by Boris Karloff on Broadway and Raymond Massey in the film |
| 30% | HENRYV | 6 | 1989 Emma Thompson movie based on a Shakespeare play: 2 wds. |
| 30% | ACTS | 4 | Plays a role on TV |
| 30% | ACT | 3 | Play a role in movies |
| 30% | AWAYFROMHER | 11 | *2007 movie based on a New Yorker short story by Alice Munro |
| 30% | THESWIMMER | 10 | *1968 movie based on a New Yorker short story by John Cheever |
| 30% | NEO | 3 | Role played by Keanu Reeves in three movies from 1999 to 2003 |