| 100% | CHRISSYSNOW | 11 | Roommate of Janet Wood and Jack Tripper played by 44-Across on 15-Across (2 wds.) |
| 40% | KELLYGRAYSON | 12 | Commander and first officer played by Adrianne Palicki on 49-Across (2 wds.) |
| 39% | ANTONIATHOMAS | 13 | Actress who plays Shaun's friend and fellow resident Claire on 15-Across: 2 wds. |
| 39% | RICHARDKIMBLE | 13 | Role played by 18- and 44-Across: 2 wds. |
| 39% | CHRISPERFETTI | 13 | "Looking" actor who plays a history teacher and ally of 15-Across: 2 wds. |
| 39% | GORDONMALLOY | 12 | Helmsman and lieutenant played by Scott Grimes on 49-Across (2 wds.) |
| 39% | EARTHSEACYCLE | 13 | Series of high fantasy novels and stories by 44-Across set on an otherworldly archipelago in an uncharted ocean (2 wds.) |
| 38% | AVONBARKSDALE | 13 | Drug dealer played by Wood Harris on "The Wire": 2 wds. |
| 38% | HARRIETTUBMAN | 13 | Abolitionist and political activist played by 44-Across in a 2019 biopic (2 wds.) |
| 38% | MILDREDHUBBLE | 13 | Accident-prone student of magic played by Bella Ramsey on 41-Across (2 wds.) |
| 38% | NEWTSCAMANDER | 13 | Character played by 15-Across in "Fantastic Beasts and Where to Find Them": 2 wds. |
| 38% | GLORIASTEINEM | 13 | Feminist journalist played by 15-Across and Alicia Vikander in a 2020 biopic based on the memoir "My Life on the Road" (2 wds.) |
| 38% | KELLYBUNDY | 10 | Ditzy character played by 15-/50-Across on "Married... with Children": 2 wds. |
| 38% | LITTLEJOE | 9 | Youngest son of 33-Across on "Bonanza," played by Michael Landon: 2 wds. |
| 38% | MANNYDELGADO | 12 | Stepson of 46-Across played by Rico Rodriguez on "Modern Family" (2 wds.) |
| 38% | CLAIREDUNPHY | 12 | Daughter of 46-Across played by Julie Bowen on "Modern Family" (2 wds.) |
| 38% | TOBIASMENZIES | 13 | 15-Across and 30-Across actor who won an Emmy for playing Prince Philip, Duke of Edinburgh, on "The Crown" (2 wds.) |
| 37% | CAROLDANVERS | 12 | Alter ego of Captain Marvel played by 13-Across and 27-Across (2 wds.) |
| 37% | DAMIANMCGINTY | 13 | Irish singer who played Rory Flanagan on "Glee" and was a member of 32-Across: 2 wds. |
| 37% | THEDOCTOR | 9 | Time Lord whose 11th incarnation was played by 15-Across on a long-running BBC sci-fi series: 2 wds. |
| 37% | THEAVENGERS | 11 | Team of superheroes created by Stan Lee and Jack Kirby for Marvel Comics on which the highest-grossing film of 2018 was based: 2 wds. |
| 37% | ALFREDBELLOWS | 13 | Psychiatrist played by Hayden Rorke on "I Dream of Jeannie": 2 wds. |
| 36% | CONNIEBRITTON | 13 | She plays country singer Rayna on 15-Across: 2 wds. |
| 36% | CYNTHIANIXON | 12 | "Sex and the City" actress who plays socialite Ada Brook on 44-Across (2 wds.) |
| 36% | ALLMYCHILDREN | 13 | Long-running daytime drama featuring the wedding of the characters played by real-life couple 15-Across and 27-Across (3 wds.) |
| 36% | DRWATSON | 8 | Holmes' assistant, played by 29-Across on 47-Across: 2 wds. |
| 36% | DEREKMORGAN | 11 | Special agent played by 39-Across on 29-Across: 2 wds. |
| 36% | GINARODRIGUEZ | 13 | Actress who plays the title role on 15-Across: 2 wds. |
| 36% | FRANFINE | 8 | Title character of 15-Across, whose first name is shared by actress Drescher who plays her: 2 wds. |
| 36% | EMILSKODA | 9 | Psychiatrist and frequent expert witness played by 47-Across on three "Law & Order" series (2 wds.) |