| 100% | BETSY | 5 | Ross who is credited with creating the first American flag |
| 50% | SCOTT | 5 | Computer scientist Fahlman who is credited with originating the first smiley emoticon |
| 43% | BETSYROSS | 9 | Woman credited with sewing the first US flag |
| 41% | ENO | 3 | Musician who is credited with popularizing the concept of the recording studio as an instrument |
| 40% | TALLCHIEF | 9 | Maria who was the first Native American prima ballerina |
| 40% | AKITA | 5 | Japanese breed that Helen Keller is credited with first bringing to the United States |
| 39% | PAUL | 4 | Beatle who was born with the first name James |
| 39% | MICHAELSTEELE | 13 | American bassist who was a part of one of the first all-female rock groups, "The Bangles" that created hits like "Manic Monday": 2 wds. |
| 39% | BUCK | 4 | O'Neil who was the first African American coach in the MLB |
| 39% | EMIL | 4 | Comedian Wakim who is the first Lebanese American cast member of "SNL" |
| 39% | LIN | 3 | Jeremy who is the only Taiwanese American with an NBA championship title |
| 39% | LIN | 3 | Jeremy who was the first Asian American to win an NBA Championship |
| 39% | SHEPARD | 7 | Alan who was the first American in space |
| 38% | SUNILEE | 7 | Gymnast who was the first Hmong American athlete to compete in the Olympics |
| 38% | GERE | 4 | Richard who was the first man featured on the cover of American Vogue |
| 38% | ETHEL | 5 | Waters who was the first Black American to host a national television show |
| 38% | POITIER | 7 | Sidney who was the first African American to win a Best Actor Oscar |
| 38% | BUNCHE | 6 | Ralph who was the first African American to be awarded the Nobel Peace Prize |
| 38% | ANNE | 4 | Bradstreet who was the first published writer from England's North American colonies (1650) |
| 38% | STEVEN | 6 | Yeun who was the first Asian American nominated for Best Actor (2020's "Minari") |
| 38% | SHAKESPEARE | 11 | Whom the first use of the nine long adjectives is credited to |
| 38% | GLENN | 5 | John who was the first American to orbit the earth |
| 38% | GUARINI | 7 | Justin, who was the first American Idol runner-up |
| 38% | PSALM | 5 | The first one begins "Blessed is the one who does not walk in step with the wicked" |
| 38% | VIOLA | 5 | Actress Davis who was the first African American to win the Triple Crown of Acting |
| 38% | WES | 3 | Actor Studi who will be the first Native American actor to receive an honorary Oscar |
| 38% | AVA | 3 | Director DuVernay who was the first African American woman nominated for a Best Picture Oscar |
| 37% | ALAN | 4 | Astronaut Shepard who was the first American in space |
| 37% | BETSYROSS | 9 | Legendary creator of the first American flag |
| 37% | JACOBY | 6 | Ellsbury who was the first Native American of Navajo descent to play in Major League Baseball |