| 100% | CONTRA | 6 | Run and gun video game published in 1988 by Konami with the characters Bill and Lance |
| 35% | CONTRA | 6 | Konami arcade game with Bill and Lance |
| 31% | MARIOBROS | 9 | Video game franchise with characters found at the ends of 17-, 20-, 53- and 58-Across |
| 31% | MARIO | 5 | First video game character to be honored with a figure in the Hollywood Wax Museum |
| 31% | LUIGI | 5 | Plumber character who is Mario's twin brother and sidekick in the video game franchise |
| 30% | ALISONBRIE | 10 | "Community" actress who voices characters in the video games "Lego Dimensions" and "Marvel Avengers Academy" (2 wds.) |
| 30% | KRISTENBELL | 11 | "The Good Place" actress who voices characters in the video games "Assassin's Creed" and "Disney Infinity" (2 wds.) |
| 30% | IDINAMENZEL | 11 | "Wicked" Tony winner who voices characters in the video games "Kingdom Hearts III" and "Disney Infinity" (2 wds.) |
| 30% | JESSEPINKMAN | 12 | Character played by Aaron Paul in "Breaking Bad", who was a crystal meth dealer and worked with the character played by 30-Across: 2 wds. |
| 30% | WASTELAND | 9 | 1988 post-apocalyptic video game published by EA |
| 30% | MORTALKOMBAT | 12 | 1995 American fantasy action film based on the video game of the same name, with characters like Liu Kang and Johnny Cage: 2 wds. |
| 30% | MOCKINGBIRD | 11 | "To Kill a ___," bestselling debut novel by Harper Lee published in 1960 that deals with race and gender issues in the American Deep South |
| 29% | HEART | 5 | & 25A Novella by Joseph Conrad narrated by the character Marlow published in 1902 volume Youth: a Narrative, and Two Other Stories |
| 29% | NPC | 3 | Video game character controlled by the game |
| 29% | AVATAR | 6 | Character created by players in video games |
| 29% | SMORE | 5 | The first recipe for one was published in "Tramping and Trailing With the Girl Scouts" (1927) |
| 28% | WARREN | 6 | With 35-Across, actor who played Clyde, one of the title characters on the run in 1967's "Bonnie and Clyde" |
| 28% | RAIDER | 6 | Video game with the character Lara Croft: Tomb __ |
| 28% | MYST | 4 | Video game franchise with the main character Atrus |
| 28% | AISHATYLER | 10 | "Whose Line Is It Anyway?" host who voices characters in the video games "Halo: Reach," "Gears of War 3," and "Watch Dogs" (2 wds.) |
| 28% | FORTNITE | 8 | Video game with Thanos as guest character in 2018 |
| 28% | TSR | 3 | Game publishing co. founded by Gary Gygax and Don Kaye in 1973 |
| 27% | FORZA | 5 | "___ Horizon," racing video game published by Microsoft Studios that is based in Colorado |
| 27% | SIMS | 4 | Characters in the video game designer Will Wright's "virtual dollhouse" |
| 27% | SEGA | 4 | Video game company with the After Burner and Virtua Fighter franchises |
| 27% | DONKEYKONG | 10 | Video game with a gorilla that first featured the main character of 43-Across (2 wds.) |
| 27% | DUST | 4 | "___: A Tale of the Wired West," single-player video game published by GTE Entertainment |
| 27% | ASYOULIKEIT | 11 | Pastoral comedy by William Shakespeare mostly set in the Forest of Arden with characters like Rosalind and Celia as main heroines: 4 wds. |
| 27% | CATSCRADLE | 10 | Game with the figures "soldier's bed" and "fish in a dish" |