| 100% | THEMATRIX | 9 | Sci-fi movie franchise starring Keanu Reeves: 2 wds. |
| 57% | WICK | 4 | "John ___," action movie franchise starring Keanu Reeves which is distributed by Lionsgate |
| 53% | DEVILSADVOCATE | 14 | "The ___," horror movie starring Keanu Reeves and Al Pacino which released in 1997: 2 wds. |
| 51% | JOHNNYMNEMONIC | 14 | 1995 film starring Keanu Reeves, based on a short story by 44-Across: 2 wds. |
| 49% | THEMATRIX | 9 | Movie in which Keanu Reeves, as Neo, says "I know kung fu": 2 wds. |
| 48% | JOHNWICK | 8 | "___ : Chapter 3 - Parabellum," action thriller starring Keanu Reeves that was one of the biggest hits of 2019: 2 wds. |
| 47% | STARWARS | 8 | Mega sci fi movie franchise began in 1977 |
| 43% | TOTALRECALL | 11 | 1990 sci-fi action movie starring 18-Across and Arnold Schwarzenegger: 2 wds. |
| 43% | STARWARS | 8 | 1977 movie that launched a huge sci-fi franchise: 2 wds. |
| 42% | STARWARS | 8 | Sci-fi movie scored by John Williams: 2 wds. |
| 42% | ESCAPEPOD | 9 | Getaway capsule in sci-fi movies: 2 wds. |
| 41% | THEMATRIX | 9 | A 1999 Sci-Fi film in which Keanu Reeves - whose birthday it is today - portrays the main character, named "Neo": 2 wds. |
| 41% | SANDRABULLOCK | 13 | Keanu Reeves' costar in "Speed" and "The Lake House": 2 wds. |
| 41% | HARRYPOTTER | 11 | Movie franchise in which Alan Rickman played Severus Snape: 2 wds. |
| 41% | STARTREK | 8 | Sci-fi franchise featuring 39-Across as Spock (2 wds.) |
| 41% | SPEED | 5 | 1994 movie starring Keanu Reeves and Sandra Bullock |
| 41% | ICEAGE | 6 | Animated movie franchise featuring a mammoth named Manny: 2 wds. |
| 40% | MINORITYREPORT | 14 | 2002 Tom Cruise sci-fi movie costarring Samantha Morton: 2 wds. |
| 40% | NEO | 3 | Keanu Reeves sci-fi role |
| 39% | CHARLIZETHERON | 14 | Actress who played Sara opposite Keanu Reeves in "Sweet November": 2 wds. |
| 39% | STARWARS | 8 | Sci-fi film franchise featuring Han Solo and Princess Leia (2 wds.) |
| 39% | SEEME | 5 | "Now You ___," movie franchise where street magicians pull off heists: 2 wds. |
| 39% | KEANUREEVES | 11 | Canadian actor who starred in the "Matrix" movie franchise: 2 wds. |
| 39% | STARTREK | 8 | Sci-fi series starring William Shatner: 2 wds. |
| 39% | NEO | 3 | Keanu Reeves' famous sci-fi character |
| 39% | CARRIEANNEMOSS | 14 | Actress who played Trinity opposite Keanu Reeves in "The Matrix": 2 wds., hyph. |
| 39% | CHAOSWALKING | 12 | Sci-fi thriller starring Daisy Ridley, Tom Holland, and 44-Across (2 wds.) |
| 39% | THEMATRIX | 9 | 1999 action-sci-fi film starring Keanu Reeves and Laurence Fishburne |
| 38% | ALIWONG | 7 | Actress who played Sasha opposite Keanu Reeves in "Always Be My Maybe": 2 wds. |
| 38% | IAM | 3 | "___ Legend" (2007 Will Smith sci-fi movie): 2 wds. |