| 100% | STARTREK | 8 | Sci-fi series starring William Shatner: 2 wds. |
| 64% | BOSTONLEGAL | 11 | Spin-off of 21-Across starring William Shatner: 2 wds. |
| 56% | ALMOSTHUMAN | 11 | Fox sci-fi series starring Karl Urban as Detective John Kennex, a cop with a robot partner: 2 wds. |
| 54% | THEORVILLE | 10 | Sci-fi TV series created by and starring Seth MacFarlane as Captain Ed Mercer (2 wds.) |
| 54% | THEMANDALORIAN | 14 | Sci-fi series starring Pedro Pascal nominated for an Outstanding Drama Series Emmy Award in 2021 (2 wds.) |
| 51% | THEPRACTICE | 11 | TV series about attorneys that featured William Shatner: 2 wds. |
| 51% | TEK | 3 | Drug in William Shatner's sci-fi series |
| 50% | TJHOOKER | 8 | Police drama starring William Shatner: 3 wds. |
| 49% | TEK | 3 | Drug central to William Shatner's sci-fi series |
| 49% | FATHERBROWN | 11 | British detective series starring Mark Williams as a crime-solving Roman Catholic priest (2 wds.) |
| 48% | STARWARS | 8 | Sci-fi movie scored by John Williams: 2 wds. |
| 48% | GETSMART | 8 | 1960s spy series starring Don Adams: 2 wds. |
| 48% | THEAVENGERS | 11 | 1960s spy series starring Patrick Macnee: 2 wds. |
| 48% | SECRETAGENT | 11 | 1960s spy series starring Patrick McGoohan: 2 wds. |
| 48% | THESAINT | 8 | 1960s spy series starring Roger Moore: 2 wds. |
| 48% | GILMOREGIRLS | 12 | 2000s TV series starring 19-Across: 2 wds. |
| 48% | ALTEREDCARBON | 13 | American dystopian sci-fi TV series starring Joel Kinnaman which is based on a novel of the same name by Richard K. Morgan: 2 wds. |
| 48% | STARWARS | 8 | Sci-fi series with droids and lightsabers: 2 wds. |
| 48% | DOCTORWHO | 9 | Long-running British sci-fi series: 2 wds. |
| 47% | STARTREK | 8 | Show with William Shatner and Nichelle Nichols: 2 wds. |
| 47% | BLACKMIRROR | 11 | Netflix sci-fi anthology series (2 wds.) |
| 46% | EMERALDCITY | 11 | New NBC series starring Adria Arjona as Dorothy: 2 wds. |
| 46% | POKERFACE | 9 | Mystery series starring Natasha Lyonne as Charlie Cale: 2 wds. |
| 46% | STARTREKPICARD | 14 | Sci-fi series starring 16-Across and 34-Across that debuted on CBS All Access on January 23, 2020 (3 wds.) |
| 46% | TRUEDETECTIVE | 13 | Current HBO series starring Matthew McConaughey and Woody Harrelson: 2 wds. |
| 46% | THEBEAR | 7 | Hulu series starring Jeremy Allen White as a chef: 2 wds. |
| 46% | JAMESBLISH | 10 | Sci-fi writer known for his "Cities in Flight" series and his "Star Trek" novels with 17-Across (2 wds.) |
| 45% | NYPDBLUE | 8 | 1993-2005 ABC series starring Dennis Franz: 2 wds. |
| 45% | THENEWSROOM | 11 | Current HBO drama series starring Jeff Daniels: 2 wds. |