| 100% | HALO | 4 | Sci-fi video game franchise with militaristic aliens |
| 55% | ALIEN | 5 | Video game franchise based on a sci-fi film franchise |
| 55% | HALO | 4 | Microsoft sci-fi video game franchise |
| 54% | TEMPLERUN | 9 | Video game franchise with evil chaser monkeys |
| 54% | DRAGONQUEST | 11 | Video game franchise with fire-breathing creatures |
| 53% | MYST | 4 | Video game franchise with the main character Atrus |
| 53% | THESIMS | 7 | Video game franchise with the cheat code "rosebud" |
| 53% | MASS | 4 | "___ Effect" (sci-fi video game franchise) |
| 48% | CSI | 3 | Franchise with a ''Hard Evidence'' video game |
| 48% | MARIOBROS | 9 | Video game franchise with characters found at the ends of 17-, 20-, 53- and 58-Across |
| 47% | SEGA | 4 | Video game company with the Super Monkey Ball franchise |
| 46% | SEGA | 4 | Video game company with the "Virtua Fighter" franchise since 1993 |
| 46% | HALO | 4 | Military-themed sci-fi franchise in video games |
| 46% | SEGA | 4 | Video game company with the After Burner and Virtua Fighter franchises |
| 45% | HALO | 4 | Sci-fi first-person shooter video game franchise |
| 45% | RAINBOWSIX | 10 | Tom Clancy video game franchise about a counterterrorist unit with a colorful title: 2 wds. |
| 43% | MASS | 4 | "___ Effect" (sci-fi video-game franchise since 2007) |
| 43% | TRON | 4 | Video game or sci-fi film |
| 43% | TONYHAWK | 8 | Legendary skateboarder with a video game franchise |
| 42% | DOOM | 4 | Video game franchise |
| 42% | TRON | 4 | Sci-fi franchise with "light cycles" |
| 41% | HALO | 4 | Famous sci-fi video game |
| 41% | AUTO | 4 | Video game franchise "Grand Theft ___" |
| 40% | METALGEAR | 9 | Video game franchise starring Solid Snake |
| 40% | CALLOFDUTY | 10 | Shooter video game franchise |
| 40% | MORTAL | 6 | __ Kombat: video game franchise |
| 40% | MORTAL | 6 | ___ Kombat, video game franchise |
| 40% | GTA | 3 | Video-game franchise with a San Andreas installment, for short |
| 40% | THEBIGS | 7 | Video game franchise starring major-league baseballers |
| 40% | HITMAN | 6 | Video game franchise featuring a clone assassin |