| 100% | CHEMIST | 7 | Scientist who creates potions with elements |
| 46% | RUTHERFORD | 10 | Scientist and physicist Ernest ___ after whom the element Rf with atomic number 104 is named |
| 46% | MARIECURIE | 10 | Scientist and chemist after whom the element Cm with atomic number 96 is named: 2 wds. |
| 45% | BERLINER | 8 | American scientist who created the gramophone |
| 43% | CHEMIST | 7 | Scientist who researches elements and compounds |
| 43% | CHEMIST | 7 | Scientist who works with test tubes |
| 43% | CHEMIST | 7 | Scientist who works with reactive substances |
| 41% | BOPP | 4 | Scientist who, with Hale, spotted a comet in 1995 |
| 41% | TESLA | 5 | Scientist who was friends with Mark Twain |
| 40% | NYE | 3 | Celebrity scientist who took a class with Sagan |
| 40% | LABBRATS | 8 | Young scientists who are impossible to work with? |
| 40% | TREY | 4 | Parker who created "South Park" with Matt Stone |
| 39% | YOCH | 4 | Florence who created Tara for "Gone With the Wind" |
| 39% | NOBEL | 5 | Scientist for whom an element is named |
| 39% | CRAFTERS | 8 | Those who create things with their hands |
| 35% | SALVADORDALI | 12 | Spanish surrealist who created "The Persistence of Memory," a painting with melted clocks: 2 wds. |
| 33% | BRIN | 4 | Sergey ___, American computer scientist and Internet entrepreneur who co-founded Google with 15a |
| 33% | ONO | 3 | Yoko who tweeted "Art. You create with love. It's simple as that." |
| 33% | EMILY | 5 | With 34-Across, "A Quiet Place Part II" actress who plays scientist Lily in "Jungle Cruise" |
| 32% | COLDPLAY | 8 | Band who had hits with The Scientist and Fix You |
| 32% | BETSY | 5 | Ross who is credited with creating the first American flag |
| 32% | TOMCLANCY | 9 | Writer who created the Jack Ryan series continued with the 2019 novel "Enemy Contact" by Mike Maden (2 wds.) |
| 32% | EDDIE | 5 | With 50-Across, "The Theory of Everything" actor who plays weather scientist James Glaisher in 30-Across |
| 32% | ERNEST | 6 | ___ Rutherford, New Zealand born physicist after whom the element with atomic number 104 was named |
| 32% | FLEMING | 7 | Scientist who discovered Penicillin |
| 31% | BERKELEY | 8 | With 50-Across, cartoonist who created "Bloom County" |
| 31% | BOHRIUM | 7 | Element with atomic number 107 which was named after a Danish physicist who studied the structure of atoms |
| 31% | BIOLOGIST | 9 | Scientist who studies living things |
| 31% | NOBEL | 5 | Scientist who discovered dynamite, Alfred __ |
| 31% | TIN | 3 | Heating with element |