| 100% | ISAACNEWTON | 11 | Scientist who experienced a great fall? |
| 51% | HUMPTYDUMPTY | 12 | Nursery rhyme character who had a great fall (2 wds.) |
| 50% | SAGAN | 5 | Scientist who said "Our planet is a lonely speck in the great enveloping cosmic dark" |
| 44% | PHYSICIST | 9 | Scientist who studies a natural science |
| 44% | SCOOBYDOO | 9 | A Great Dane who solves mysteries |
| 43% | SATONAWALL | 10 | What Humpty Dumpty did before having a great fall |
| 42% | SALK | 4 | Scientist who won a 1977 Presidential Medal of Freedom |
| 42% | BOPP | 4 | Scientist who, with Hale, spotted a comet in 1995 |
| 41% | BEAMAZED | 8 | "You will experience a great and unexpected surprise!" (go to 48-Across) |
| 41% | EVACRANE | 8 | Nuclear scientist who was also a bee scientist |
| 40% | AVOGADRO | 8 | Italian scientist who lent his name to a number |
| 40% | CAMP | 4 | Experience the great outdoors, in a way |
| 40% | PACQUIAO | 8 | Manny who is a great Filipino boxer |
| 40% | XXXXXXX | 7 | Falls from a great height |
| 39% | DANTE | 5 | Who wrote "A great flame follows a little spark" |
| 39% | NYE | 3 | Celebrity scientist who took a class with Sagan |
| 39% | NYE | 3 | Scientist Bill who always wears a bow tie |
| 39% | PROLIFIC | 8 | Artist who creates a great amount of work |
| 39% | SKYDIVE | 7 | Fall from a great height recreationally |
| 39% | DUPE | 4 | Sucker who falls for a scam |
| 38% | NAIVE | 5 | A person with no experience who is easily fooled |
| 38% | SAP | 3 | Person who might fall for a scam |
| 38% | NOAH | 4 | Biblical figure who survived a Great Flood |
| 38% | NET | 3 | What catches a tightrope walker who falls |
| 38% | ALICE | 5 | Girl who fell down a rabbit hole |
| 38% | PAVAROTTI | 9 | ''A great volcano of a man who sang fire,'' per Bono |
| 38% | MOBY | 4 | Musician who's a great-great-grandnephew of Herman Melville |
| 38% | BROCA | 5 | Scientist for whom a part of the brain is named |
| 37% | ACROBAT | 7 | One who might be in for a fall |
| 37% | SAP | 3 | Person who might fall for a con game |